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MAPK13 — SP1

Text-mined interactions from Literome

Milanini-Mongiat et al., J Biol Chem 2002 : Mutation of these sites to alanines decreases by half the MAPK dependent transcriptional activity of Sp1 , in the context of the VEGF promoter, in SL2 Drosophila cells devoid of the endogenous Sp1 protein
Lam et al., Biochemistry 2003 (MAP Kinase Signaling System) : Sp1 binding activity increased with either MAPK or PKC
Atkins et al., Int J Dev Neurosci 2003 : Addition of the PKC inhibitor ( staurosporine ) diminished NGF and Pb-induced Sp1 DNA binding, while the MAPK inhibitor ( PD 98059 ), completely abolished both basal and induced Sp1 DNA binding ... These findings demonstrate that Sp1 DNA binding is regulated by PKC and MAPK , which may serve as mediators through which Pb may indirectly modulate Sp1 DNA binding
Carnesecchi et al., Exp Cell Res 2006 : We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha
Xu et al., Cancer Res 2007 (Brain Neoplasms...) : EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen activated protein kinase dependent activation of the Sp1/Sp3 transcription factors in human gliomas ... Enhanced DNA binding by Sp1/Sp3 requires p38-MAPK activity and correlates with increased phosphorylation of the Sp1 transcription factor
Pan et al., Journal of thrombosis and haemostasis : JTH 2008 (Thrombosis) : Inhibition of p38 MAPK abrogated basal and quercetin induced t-PA expression and promoter activity, as well as quercetin induced Sp1 binding to Sp1b