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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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IL1B — SRC

Text-mined interactions from Literome

Salinthone et al., Am J Physiol Gastrointest Liver Physiol 2004 (Inflammation) : Expression of IL-1beta , IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor
Jalal et al., J Am Soc Nephrol 2006 : Src activation of NF-kappaB augments IL-1beta induced nitric oxide production in mesangial cells ... In agreement with the pharmacologic inhibition studies, siRNA directed against c-Src specifically limited c-Src protein expression and inhibited IL-1beta mediated induction of NF-kappaB DNA binding activity, whereas control siRNA had no effect
Davis et al., Proc Natl Acad Sci U S A 2006 : We show here that IL-1beta mediated activation of the protein tyrosine kinase Src depended on a MyD88 interaction with the IL-1RI/IL-1RAcP complex
Davis et al., J Neurochem 2006 : IL-1beta induces a MyD88 dependent and ceramide mediated activation of Src in anterior hypothalamic neurons
Lin et al., J Cell Physiol 2007 (Lung Neoplasms) : Src , PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta stimulated Src, PDGFR, and Akt phosphorylation, respectively
Tsakiri et al., Br J Pharmacol 2008 : We demonstrate that IL-1beta induced Src kinase activation triggers the phosphorylation of the NMDA receptor NR2B subunit, leading to activation of Ca ( 2+ ) /calmodulin dependent protein kinase II ( CamKII ) and the nuclear transcription factor CREB
Sheikpranbabu et al., Journal of nanobiotechnology 2009 : We report that VEGF and IL-1beta-stimulate endothelial permeability via Src dependent pathway by increasing the Src phosphorylation and Ag-NP block the VEGF-and IL-1beta induced Src phosphorylation at Y419
Sheikpranbabu et al., Vascul Pharmacol 2010 : In addition, overexpression of DN Src blocked both VEGF-and IL-1beta-stimulation of permeability, proliferation and migration, while overexpression of CA Src overpowers the inhibitory action of PEDF on permeability, proliferation and migration