Gene interactions and pathways from curated databases and text-mining

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MITF — TCF7

Pathways - manually collected, often from reviews:

  • KEGG Melanogenesis: LEF1/TCF7/TCF7L1/TCF7L2 → MITF (gene expression, expression)

Text-mined interactions from Literome

Carreira et al., J Biol Chem 2000 : Here we provide several lines of evidence to suggest that Mitf may regulate the expression of the Tbx2 transcription factor , a member of the T-box family of proteins implicated in the maintenance of cell identity
Hou et al., Proc Natl Acad Sci U S A 2006 : In both zebrafish and mice, one transcription factor , SOX10, controls the expression of another, MITF ( microphthalmia associated transcription factor ), which in turn regulates a set of genes critical for pigment cell development and pigmentation
Yokoyama et al., J Biochem 2006 (Coloboma...) : SOX10 transcription factor and endothelin receptor type B (EDNRB) are responsible for WS type 4 ( WS4 ), which also exhibits megacolon, while microphthalmia associated transcription factor ( MITF ) is responsible for WS2 , which is not associated with megacolon
Katoh et al., Neoplasia (New York, N.Y.) 2011 (Melanoma...) : Activation of the long terminal repeat of human endogenous retrovirus K by melanoma-specific transcription factor MITF-M
Hari Kishore et al., Mol Endocrinol 2012 : We conclude that hypoxia and stabilization of the transcription factor HIF-1a result in up-regulation of differentiated embryo chondrocyte expressed gene 1, loss of MiTF , and absence of MiTF binding to the IL-8 promoter, which in turn leads to up-regulation of IL-8 gene expression