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MITF — TCF7
Pathways - manually collected, often from reviews:
-
KEGG Melanogenesis:
LEF1/TCF7/TCF7L1/TCF7L2
→
MITF
(gene expression, expression)
Text-mined interactions from Literome
Carreira et al., J Biol Chem 2000
:
Here we provide several lines of evidence to suggest that
Mitf may
regulate the expression of the Tbx2
transcription factor , a member of the T-box family of proteins implicated in the maintenance of cell identity
Hou et al., Proc Natl Acad Sci U S A 2006
:
In both zebrafish and mice, one
transcription factor , SOX10,
controls the expression of another,
MITF ( microphthalmia associated transcription factor ), which in turn regulates a set of genes critical for pigment cell development and pigmentation
Yokoyama et al., J Biochem 2006
(Coloboma...) :
SOX10 transcription factor and endothelin receptor type B (EDNRB) are responsible for WS type 4 ( WS4 ), which also exhibits megacolon, while microphthalmia associated
transcription factor ( MITF ) is
responsible for
WS2 , which is not associated with megacolon
Katoh et al., Neoplasia (New York, N.Y.) 2011
(Melanoma...) :
Activation of the long terminal repeat of human endogenous retrovirus K by melanoma-specific
transcription factor MITF-M
Hari Kishore et al., Mol Endocrinol 2012
:
We conclude that hypoxia and stabilization of the
transcription factor HIF-1a
result in up-regulation of differentiated embryo chondrocyte expressed gene 1, loss of
MiTF , and absence of MiTF binding to the IL-8 promoter, which in turn leads to up-regulation of IL-8 gene expression