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NFKBIA — TCF7

Text-mined interactions from Literome

Algarté et al., Mol Cell Biol 1999 : Mutation of either the kappaB1 site or the Sp1 site abolished transcription factor binding to the respective sites and the inducibility of the IkappaBalpha promoter in transient transfection studies
Fan et al., J Mol Biol 2001 : Currently known DLC8 targets include neuronal nitric oxide synthase ; the proapoptotic Bcl-2 family member protein designated Bim ; a Drosophila RNA localization protein Swallow, myosin V, neuronal scaffolding protein GKAP, and IkappaBalpha , an inhibitor of the NFkappaB transcription factor
Huxford et al., J Mol Biol 2002 : IkappaBalpha inhibits transcription factor NF-kappaB activity by specific binding to NF-kappaB heterodimers composed of p65 and p50 subunits
Shumway et al., Biochem J 2004 (Lymphoma, B-Cell) : Inducible activation of the transcription factor NF-kappaB ( nuclear factor kappaB ) is classically mediated by proteasomal degradation of its associated inhibitors, IkappaBalpha ( inhibitory kappaBalpha ) and IkappaBbeta
Jonassen et al., Urol Res 2005 (Kidney Calculi) : In addition, renal cell oxalate exposure promotes rapid degradation of IkappaBalpha , an endogenous inhibitor of the NF-kappaB transcription factor
Chang et al., J Pharmacol Sci 2009 : Furthermore, the LPS induced degradation of cytosolic IkappaB-alpha and activation of nuclear transcription factor-kappaB ( NF-kappaB ) were also inhibited by FC-77
Nagarajan et al., Bioorg Med Chem 2010 : IkappaB kinase (IKK) is critical in proinflammatory cytokine induced IkappaBalpha phosphorylation and subsequent activation of the nuclear transcription factor NF-kappaB complex
Baldi et al., J Biol Chem 1996 : NF-kappa B is readily activated from normally inhibited cytoplasmic stores by induced proteolytic degradation of I kappa B-alpha , a principal inhibitor of this transcription factor
Chen et al., Biochem Biophys Res Commun 1997 : Western blot analysis suggests that the inhibitory effect of tetrandrine on NF-kappa B activation can be attributed to its ability to suppress signal induced degradation of I kappa B alpha , a cytoplasmic inhibitor of the NF-kappa B transcription factor
Chen et al., Arch Biochem Biophys 1997 : Both silica and lipopolysaccharide (LPS) induce a rapid degradation of I kappa B alpha , an intracellular inhibitor of the nuclear factor (NF)-kappa B transcription factor
Abu-Amer et al., J Biol Chem 1998 : Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha