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CD28 — XRCC6

Text-mined interactions from Literome

Carey et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : CD28 inhibits Rap1 activation because it selectively stimulates an extrinsic Rap1 GTPase activity ... The ability of CD28 to stimulate Rap1 GTPase activity was dependent on the tyrosine kinase Lck
Grader-Beck et al., Blood 2003 : Increase of cAMP also inhibited activation of Rap1 mediated by TCR/CD3 plus CD28 ... Thus, TCR plus CD28 mediated activation of ERK1/2 and PKB, cytokine production, and cell cycle progression, all of which are inhibited by cAMP, require activation of Ras but not Rap1
Li et al., Blood 2005 : T-cell receptor (TCR)-CD3/CD28 mediated activation of Rap1 and Akt was retained in Tregs, but activation of Ras, mitogenactivated protein kinase 1/2 ( MEK1/2 ), and extracellular signal regulated kinase 1/2 ( Erk1/2 ) was impaired