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Nakamura et al., Biochem Pharmacol 2003
:
However, inhibition of Stx2 mediated caspase activity by terbutaline was partially blocked by cAMP-PKA inhibitors
Dejda et al., Pharmacol Rep 2005
(Neurodegenerative Diseases) :
The mechanism underlying neuroprotective properties of PACAP seems to involve activation of adenylyl cyclase ( AC ) -- > cyclic adenosine 3',5'-mono-phosphate ( cAMP ) -- > protein kinase A (PKA) and mitogen activated protein ( MAP ) kinase pathways, and inhibition of caspase-3 Almeida et al., Hum Mol Genet 2011
(Cryopyrin-Associated Periodic Syndromes) :
NOMID tumor cells showed high PKA activity, and an increase in their cAMP signaling led to PKA-specific activation of caspase-1 ... Increased PKA led to inflammation independent activation of caspase-1 via over-expression of the proto-oncogene ( and early osteoblast factor ) Ets-1