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CYP17A1 — PRKACG

Text-mined interactions from Literome

Laurich et al., Endocrinology 2002 (Leydig Cell Tumor) : Protein kinase A (PKA) inhibition with H-89 blocked Cyp17 mRNA induction, suggesting that MIS interferes with the PKA signal transduction pathway
Dammer et al., J Biol Chem 2008 : Further, we postulated that PKA evokes changes in the phosphorylation status of CtBP1 that control the ability of the protein to bind to steroidogenic factor-1 and the coactivator GCN5 ( general control nonderepressed 5 ) and repress CYP17 gene expression ... We provide evidence that PKA 1 ) induces metabolic changes in the adrenal cortex and 2 ) phosphorylates CtBP proteins, particularly CtBP1 at T144, resulting in CtBP protein partnering and ACTH dependent CYP17 transcription