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PRKACG — SHH

Text-mined interactions from Literome

Tiecke et al., Dev Biol 2007 : Expressing dominant negative PKA also induced extra, sometimes multiple digits, from anterior limb bud demonstrating the negative role in Shh signaling
Barzi et al., J Cell Sci 2010 : Cerebellar granular neuronal precursors ( CGNPs ) proliferate in response to the mitogenic activity of Sonic hedgehog (Shh) , and this proliferation is negatively regulated by activation of cAMP dependent protein kinase (PKA) ... Here we report that, in the presence of Shh, inactive C-PKA accumulates at the cilium base of proliferative CGNPs whereas removal of Shh triggers the activation of PKA at this particular location