Shao et al., EMBO Rep 2003
:
Here, we show that Cbl deficiency results in enhanced activation of Rap1 ... Thus, Cbl negatively regulates Rap1 activation, probably through a proteolysis independent E3-ubiquitin-ligase activity of Cbl that modulates protein-protein interactions
Zhang et al., J Biol Chem 2003
:
Thus, Cbl-b plays a negative role in Crk-L-C3G mediated Rap1 and LFA-1 activation in T cells