Schleicher et al., J Exp Med 2007
(Leishmaniasis, Visceral) :
In vitro, pDCs did not endocytose Leishmania promastigotes but nevertheless released interferon (IFN)-alpha/beta and interleukin (IL)-12 in a TLR9 dependent manner
Haas et al., Immunology 2009
:
Single stranded versus multimeric phosphorothioate modified CpG oligodeoxynucleotides ( ODNs ) undergo differential endosomal trafficking upon uptake into plasmacytoid dendritic cells ( pDCs ), correlating with Toll-like receptor-9 dependent pDC maturation/activation ( single stranded B-type CpG ODN ) or interferon-alpha ( IFN-alpha ) induction ( multimeric A-type CpG ODN ), respectively