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LTA — TAT

Text-mined interactions from Literome

Sastry et al., J Biol Chem 1990 : Since TNF has been shown to function as a growth factor for several cell types, our results showing induction of TNF-beta by tat indicate the possibility that a growth-stimulatory role of HIV-1 tat on Kaposi 's sarcoma cells is mediated through TNF-beta
Sharma et al., Biochem Biophys Res Commun 1995 : In addition to the varied effects of tat on the steady state levels of cytokine mRNAs, tat induced the secretion of TNF-beta preferentially in both B and T cell lines, either by itself as in Raji B cell line or synergistically upon PMA + PHA stimulation as in Jurkat T cell line
Buonaguro et al., J Virol 1994 : Here we show that ( i ) the NF-kappa B and Sp1 binding sites of the TNF beta promoter are required for Tat mediated transactivation and ( ii ) a predicted stem-loop structure in the TNF beta mRNA leader region, which resembles the Tat-responsive element of the HIV-1 long terminal repeat ( TAR ) and which is therefore termed TAR-like, is essential for TNF beta transactivation by Tat