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Saci et al., Biochem J 2000
:
Experiments performed with inhibitors of tyrosine kinases indicated that both Src-family kinases and Syk contribute to phosphorylation of Cbl and its consequent association with PI 3-kinase Waldeck-Weiermair et al., J Cell Sci 2008
(Calcium Signaling) :
Furthermore, Syk inhibits phosphoinositide 3-kinase (PI3K) that represents a key protein in the transduction of GPR55 originated signaling
Burger et al., Blood 2013
(Leukemia, Lymphocytic, Chronic, B-Cell) :
This concept recently gained momentum after the clinical activity of kinase inhibitors that target BCR signaling ( spleen tyrosine kinase , Bruton tyrosine kinase, PI3Kd inhibitors ) was established