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A2M — CHAT

Text-mined interactions from Literome

Hu et al., J Neurosci Res 1994 (Nerve Degeneration) : Monoamine activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin dependent neuronal functions
Mazzoni et al., Neuroscience 1997 : However, while the native antiprotease can slightly but significantly decrease choline acetyltransferase activity, trypsin activated alpha 2-macroglobulin , in the nanomolar range, induces as marked a decrease in this enzyme activity as that noted with transforming growth factor-alpha ... In addition, trypsin activated alpha 2-macroglobulin , in the nanomolar range, can affect choline acetyltransferase in a dual manner, up-regulating it at low concentrations while down regulating it at higher ones
Hu et al., J Neurosci Res 1998 : In this report, we tested the effect of intracranially infused serotonin activated rat alpha1M ( 5HT-alpha1M ) on the concentration of dopamine ( DA ) in the corpus striatum in vivo and the effect of 5HT activated rat alpha1M and alpha2M on the choline acetyltransferase (ChAT) activity upon embryonic basal forebrain neurons in culture