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BCL6 — STAT6

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL4-mediated signaling events: BCL6 (BCL6) → STAT6 (dimer) complex (STAT6) (T-helper 2 cell differentiation, inhibits)
  Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL4-mediated signaling events: BCL6 (BCL6) → STAT6 (dimer) complex (STAT6) (transcription, inhibits)
  Harris et al., Mol Cell Biol 1999*, Harris et al., J Biol Chem 2005*, Gascan et al., J Exp Med 1991, Kim et al., Eur J Immunol 1995*, Delphin et al., J Exp Med 1995, Köhler et al., Eur J Immunol 1993, Takeda et al., Nature 1996, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IRF4/BCL6 complex (IRF4-BCL6) → STAT6 (dimer)/PARP14 complex (STAT6-PARP14) (transcription, inhibits)
  Gupta et al., J Exp Med 1999, Schroder et al., J Immunol 2002, Goenka et al., Proc Natl Acad Sci U S A 2006, Kotanides et al., Science 1993, Takeda et al., Nature 1996, Ryan et al., Immunity 1996
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Harris et al., Mol Cell Biol 1999 : The apparent dysregulation of IgE production is abolished in BCL-6 ( -/- ) Stat6 ( -/- ) mice, indicating that BCL-6 regulation of Ig class switching is dependent upon Stat6 signaling
Wurster et al., J Biol Chem 2002 : Interleukin-4 mediated protection of primary B cells from apoptosis through Stat6 dependent up-regulation of Bcl-xL ... We show that expression of the Bcl-2 family member, Bcl-xL , is induced maximally by IL-4 and anti-IgM/IL-4 in a Stat6 dependent manner
Harris et al., J Biol Chem 2005 : Examination of BCL-6-/- and BCL-6-/-Stat6-/- mice has demonstrated that BCL-6 is a repressor of IgE and that Stat6 is still required for the interleukin-4 (IL-4) induction of class switching to IgE in B cells lacking BCL-6
Ritz et al., Oncotarget 2013 (Lymphoma, B-Cell...) : STAT6 mediated BCL6 repression in primary mediastinal B-cell lymphoma ( PMBL )