◀ Back to FOXO3
FOXO3 — PTEN
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FOXO3
→
PTEN
(increases, PTEN Activity)
Evidence: In PTEN-deficient prostate carcinoma cell lines, FOXO1 and FOXO3 are cytoplasmically sequestered and inactive (Modur et al., 2002). In addition, the expression level of tumor necrosis factor family member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; Modur et al., 2002), a proapoptotic effector, is decreased (Modur et al., 2002).
Text-mined interactions from Literome
Li et al., J Cereb Blood Flow Metab 2009
(Hypoxia-Ischemia, Brain) :
Furthermore, we found that
PTEN inhibition by bisperoxovanadium significantly
increased the phosphorylation of Akt and
FOXO3a , decreased the nuclear translocation of FOXO3a, and inhibited Bim expression after HI
Vahtola et al., Cardiovascular diabetology 2010
(Diabetes Complications...) :
In the GK rat myocardium, Akt- and
FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was
increased concomitantly with increased
PTEN protein expression
Dai et al., Cancer Res 2010
(Brain Neoplasms...) :
Decreased
PTEN in turn
resulted in the hyperactivation of Akt, which led to phosphorylation and cytoplasmic retention of
FoxO3a
Weidinger et al., J Clin Endocrinol Metab 2011
(Carcinoma...) :
In vivo, we observed a direct correlation between
PTEN expression and the transcriptional
activation of
FOXO3
Luo et al., Cell death & disease 2013
(Colorectal Neoplasms) :
PTEN regulated
AKT/FoxO3a/Bim signaling contributes to reactive oxygen species mediated apoptosis in selenite treated colorectal cancer cells ... Additionally, we discovered that
FoxO3a mediated upregulation of
PTEN exerted a further inhibitory effect on the AKT survival pathway