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Chen et al., Mol Pharmacol 1999 : Tyrosine kinase inhibitor, genestein, attenuated the LPS induced activation of both p44/42 MAPK and p38 , whereas the PKC inhibitors, Ro 31-8220 and calphostin C, or long-term treatment with 12-O-tetradecanoylphorbol-13-acetate resulted in inhibition of p44/42 MAPK activation, but had only a slight effect on p38 activation, indicating that LPS mediated PKC activation resulted in the activation of p44/42 MAPK
Hale et al., J Immunol 1999 (Inflammation) : Abs specific for mono- and dual phophorylated forms of p38 suggested that LPS induces dual phosphorylation of p38alpha , but primarily mono-phosphorylation of p38delta
Kraatz et al., J Surg Res 1999 : LPS activated MAPK, SAPK, and p38
Rizoli et al., J Trauma 1999 : Hypertonicity had no effect on CD11b or CD14, caused a weak p38 phosphorylation, and completely prevented the LPS induced p38 phosphorylation and CD11b up-regulation
Lakics et al., J Immunol 2000 : More strikingly, LPS induced phosphorylation of p38 mitogen activated protein kinase and c-Jun N-terminal kinase was strongly repressed by Bcl-xL overexpression, offering a possible mechanism for the inhibition of LPS induced cytokine production
Chan et al., Am J Physiol Cell Physiol 2001 : We found that extracellular signal regulated kinase ( ERK ) augmented and p38 ( mapk ) inhibited IFN-gamma + LPS induction of iNOS
Bainbridge et al., Acta Odontol Scand 2001 (Periodontitis) : Correspondingly, although it activates p38 MAP kinase in human monocytes, P. gingivalis LPS does not activate p38 nor ERK MAP kinase in endothelial cells
Li et al., J Neurosci Res 2001 (MAP Kinase Signaling System) : Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) induced a time dependent activation of both p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB), with consequent increases in interleukin-1alpha (IL-1alpha), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide ( NO ) production
Hur et al., FEBS Lett 2001 (MAP Kinase Signaling System) : LPS induced activation of both p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinase ( ERK ) in C6 cells
Utsugi et al., J Leukoc Biol 2002 : LPS induced IL-12 production and p38 mitogen activated protein ( MAP ) kinase activation were enhanced by GSH-OEt but suppressed by DEM. Selective p38 inhibitors showed that p38 promoted GSH-OEt enhanced IL-12 production
Lu et al., Chin J Traumatol 2001 : P38MAPK was activated by LPS ( 100 ng/ml ) with peak activation at 30 minutes
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38 , Jnk, Erk, or Akt
Bozinovski et al., J Biol Chem 2002 (MAP Kinase Signaling System) : LPS markedly activated Akt and Erk1/2, but not p38 , in a GM-CSF dependent manner in direct temporal association with NFkappaB and AP-1 activation
Kinjyo et al., Immunity 2002 : LPS induced I-kappaB and p38 phosphorylation was upregulated in SOCS1 ( -/- ) macrophages, and forced expression of SOCS1 suppressed LPS induced NF-kappaB activation
Lai et al., J Immunol 2003 : Thus, LPS induction of MMP-1 production by monocytes is regulated by both ERK1/2 and p38 , whereas MMP-9 stimulation occurred mainly through the ERK1/2 pathway
Veres et al., J Pharmacol Exp Ther 2004 (Inflammation) : Namely, it dramatically attenuated the activation of the LPS induced extracellular signal regulated kinase ( ERK ) 1/2 and p38 mitogen activated protein ( MAP ) kinase in a tissue-specific manner
Woo et al., J Immunol 2004 : Interestingly, LPS induced MMP-9 expression and p38 kinase phosphorylation were shown to be suppressed by the antioxidant N-acetylcysteine and the flavoenzyme inhibitor diphenyleneiodonium chloride, but not by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor
Jeng et al., Immunol Lett 2005 : Sesamin and sesamolin also reduced LPS activated p38 mitogen activated protein kinase ( MAPK ) and nuclear factor (NF)-kappaB activations
Lu et al., J Biol Chem 2005 : Whereas macrophages from Rip2-deficient mice showed impaired NF-kappaB and p38 mitogen activated protein kinase activation and reduced cytokine production in response to LPS stimulation, LPS signaling was intact in macrophages from mice that express Rip2 kinase-dead mutant
Kim et al., Immunopharmacol Immunotoxicol 2005 : Mercury activated p38 mitogen activated protein kinase ( MAPK ) and additively increased LPS induced p38 MAPK phosphorylation
Lo et al., J Ethnopharmacol 2005 (Pulmonary Edema) : Western blotting analysis results indicated that all of them significantly inhibited LPS induced iNOS, TGF-beta, p38MAPK , and ICAM-1 expressions in the lung tissues
Husted et al., J Surg Res 2005 : The data show that delta2- but not delta1-opioid agonists suppress LPS induced p38 MAPK activation and expression of TNFalpha and MIP-2
Xue et al., J Pharmacol Exp Ther 2006 : Studies in THP-1 cells to address potential mechanism ( s ) showed that tipifarnib partially inhibited LPS induced p38 phosphorylation
Thakur et al., Am J Physiol Gastrointest Liver Physiol 2006 : gAcrp suppressed LPS stimulated ERK1/2 and p38 phosphorylation as well as IkappaB degradation at 100-1,000 ng/ml in Kupffer cells from both pair- and ethanol fed rats
Maezawa et al., Journal of neuroinflammation 2006 : Our results suggest that LPS activation of innate immune response in TR APOE glia results in opposing outcomes from microglia and astrocytes as a result of TR APOE dependent activation of p38MAPK or NF-kappaB signaling in these two cell types
Nakamura et al., J Biol Chem 2006 (MAP Kinase Signaling System) : In Raw 264.7 cells treated with MNSFbeta small interfering RNA ( siRNA ) lipopolysaccharide (LPS) induced ERK1/2 activation was enhanced and LPS induced JNK and p38 activation was unaffected
Liu et al., J Neurosci Res 2006 : NO had no effect on LPS stimulated ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades
Thomas et al., J Biol Chem 2006 : LPS induced activation of intracellular signaling molecules, STAT1 Tyr-701, STAT1 Ser-727, and Akt, but not p38 , JNK, and ERK MAPK proteins, was significantly diminished in IFN-beta ( -/- ) versus IFN-beta ( +/+ ) macrophages
Sherry et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : LPS dependent stimulation of PI3K activity, ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice
Poulaki et al., FASEB J 2007 (Leukostasis...) : 17-AAG treatment significantly suppressed the LPS induced increase in retinal leukocyte adhesion ; vascular leakage ; NF-kappaB, HIF-1alpha, p38 , and PI-3K activity ; and VEGF, TNF-alpha, and IL-1beta levels
Li et al., J Endotoxin Res 2007 : When added to human macrophage culture, rFC blocks the LPS induced phosphorylation of p38 , which, in turn, inhibits the consequential overexpression of TNF-alpha and IL-8
Gutiérrez-Venegas et al., Int Immunopharmacol 2007 : Our results showed that LPS treatment induces activation of extracellular signal related kinase 1/2 ( ERK1/2 ), p38 , and c-jun-NH ( 2 ) -terminal kinase ( JNK )
Yang et al., Molecular vision 2007 : Pretreatment with minocycline or sulforaphane for 1 h before LPS administration inhibited LPS induced microglial morphological change and inhibited LPS induced upregulation of p-p38 , but had no effect on the expression of p-p44/42, p-JNK, and the p65 subunit of NF-kappaB
Cheng et al., Cell Mol Neurobiol 2007 (MAP Kinase Signaling System) : Moreover, LPS activated extracellular signal regulated kinase ( ERK1/2 ), P38 and stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and induced their phosphorylation
Miksa et al., Int J Mol Med 2008 (Inflammation) : LPS induced phosphorylation of ERK1/2, p38 and JNK is more enhanced in RPM compared to TGPM
Zemans et al., Cell Immunol 2009 : Herein, we show that the Tec kinases are activated in LPS stimulated human neutrophils and that inhibition of the Tec kinases, with leflunomide metabolite analog ( LFM-A13 ), decreased LPS induced JNK, but not p38 , activity
Nam et al., Can J Physiol Pharmacol 2009 : In addition, Chunghyuldan significantly decreased LPS induced phosphorylation of the ERK1/2 and p38 signaling proteins
Li et al., J Ethnopharmacol 2009 : LPS induced phosphorylation of ERK1/2 and p38 were inhibited by TMP
Folco et al., J Biol Chem 2009 (Inflammation...) : We demonstrate that pretreatment of these cells with adiponectin inhibits phosphorylation of nuclear factor kappaB inhibitor ( IkappaB ), c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase ( MAPK ), induced by either lipopolysaccharide (LPS) or tumor necrosis factor (TNF) alpha, as well as STAT3 phosphorylation induced by interleukin-6 (IL6)
Zhang et al., Br J Pharmacol 2009 : These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via CRF ( 2 ) receptors and the activation of p38MAPK and NF-kappaB
Matera et al., Clinical and vaccine immunology : CVI 2009 : V. parvula LPS stimulated cytokine induction, as well as p38 MAPK activation, are TLR4 dependent features
Liu et al., Basic Clin Pharmacol Toxicol 2010 : Signal transduction studies showed that the pre-treatment of HUVECs with COS ( 50-200 microg/ml ) for 24 hr markedly inhibited the LPS induced over-expression of phosphorylated p38 mitogen activated protein kinase ( MAPK ), phosphorylated ERK1/2 and nuclear factor kappaB (NF-kappaB)
Tsukamoto et al., Int Immunol 2010 : Time course studies on mCD14 positive cells have demonstrated that LPS stimulation induces rapid activation of nuclear factor-kappaB and p38 in the presence of LBP ( TLR4/MD-2 receptor dimerization ) as compared with stimulation without LBP ( receptor non-dimerization )
Yoon et al., Food Chem Toxicol 2010 : AFE inhibited LPS induced ERK, JNK, and p38 phosphorylation
Chao et al., J Agric Food Chem 2010 : At the same time, honokiol not only inhibited nitric oxide expression in LPS stimulated murine macrophages but also inhibited the LPS induced phosphorylation of ERK1/2, JNK1/2, and p38
Tang et al., Am J Med Sci 2010 (Cell Transformation, Neoplastic...) : LPS increased the phosphorylation of ERK1/2 and P38 and activated NF-kappaB
He et al., J Cell Biochem 2010 : The activation of TLR4 by LPS modulated the expression of TLRs, induced the phosphorylation of NF-kappaB, P38 , and ERK42/44, and up-regulated the gene expression of cytokines IL-8, IFN-alpha, IFN-beta, and TNF-alpha, suggesting EPCs expressed functional TLR4
Matsui et al., Anesth Analg 2010 : Spinal microglia isolated from Sprague-Dawley neonatal rats were cultured with lipopolysaccharide (LPS) or substance P ( SP ) alone, with LPS in combination with SP, and with LPS in the presence of each inhibitor of cyclooxygenase (COX), NO synthase 2 (NOS2) or p38 mitogen activated protein kinase ( p38 ), or minocycline for 24 hours and 48 hours
Holen et al., Fish Shellfish Immunol 2011 : Indicating a p38 MAPK feedback loop, LPS significantly inhibited the expression of p38MAPK itself in both diets, while SB202190 increased p38MAPK expression especially in the VO diet group
Wu et al., J Surg Res 2012 : LPS induced p38 MAPK activation and NF-?B signal pathways first, followed by CBP activation
Zhang et al., Cardiovasc Res 2012 (Endotoxemia...) : LPS induced extracellular signal regulated kinase ( ERK ) 1/2 and p38 phosphorylation in the myocardium was prolonged in MKP1 ( -/- ) mice
Joo et al., Gut and liver 2012 : LPS induced phosphorylation of ERK1/2, JNK, and p38 was inhibited by EGCG
Huang et al., PloS one 2012 (Edema...) : Inotilone also inhibited LPS induced ERK, JNK, and p38 phosphorylation
Wei et al., J Biochem Mol Toxicol 2012 (Acute Lung Injury...) : In RAW 264.7 macrophage cells, cardamonin also showed selective inhibition of P38 phosphorylation induced by LPS
Oh et al., Am J Chin Med 2012 (Inflammation...) : Additionally, CUP inhibited the LPS induced phosphorylation of extracellular signal regulated kinase ( ERK ), p38 , and c-Jun NH ( 2 ) -terminal kinase ( JNK ) MAPK, and suppressed I?Ba degradation and nuclear translocation of NF-?B
Barry et al., Cell Host Microbe 2012 : Impaired stimulation of p38a-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes ... We find that while avirulent C. burnetii LPS ( avLPS ) stimulates host p38a-MAPK signaling required for proper trafficking of bacteria containing compartments to lysosomes for destruction, pathogenic C. burnetii LPS ( vLPS ) does not
Fujimoto et al., Neurobiol Dis 2013 (Disease Models, Animal...) : LPS-RS blocked TNC induced TLR4 upregulation, JNK and p38 activation, and vasoconstrictive effects
Liu et al., Eur J Pharmacol 2013 : Signal transduction studies indicated that DSC significantly inhibited LPS induced phosphorylation of Akt, but not c-Jun N-terminal kinase 1/2, p38 , or extracellular signal regulated kinase 1/2
Nick et al., J Immunol 1996 : We report that exposure of neutrophils to LPS results in the phosphorylation and activation of a p38 mitogen activated protein ( MAP ) kinase, occurring in a concentration dependent manner, with maximum response at 20 to 25 min. Partial purification of a p38 MAP kinase by ion exchange chromatography established it as distinct from the p42/p44 ( extracellular signal regulated kinases ( ERK-1 and ERK-2 ) MAP kinases )
Lo et al., J Surg Res 1998 : Iloprost also attenuated the activation of P44/P42 and P38 induced LPS