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IL1RN — IRF6

Text-mined interactions from Literome

van Crevel et al., J Immunol Methods 1999 (Tuberculosis) : LPS induces the production of TNFalpha, IL-1beta, IL-1ra and IL-10 ; PHA induces the production of IFNgamma and IL-10
Schytte Blix et al., J Periodontal Res 1999 (Aggressive Periodontitis...) : We have studied the effect of lipopolysaccharide (LPS) extracted from these periodontopathogenic bacteria on synthesis of the proinflammatory cytokines, interleukin-1beta(IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) in human whole blood ... Similarly, LPS from A. actinomycetemcomitans > or =0.1 ng/ml resulted in production of IL-1ra , while LPS from E. coli 026 : B6 had to be added at > or =10 ng/ml to obtain similar effects
Kovalovsky et al., Neuroimmunomodulation 1999 : ACTH exerted a dose dependent inhibitory effect on lipopolysaccharide (LPS) induced IL-1ra production and mRNA expression
Andersen et al., Autoimmunity 1999 (Lupus Erythematosus, Systemic) : LPS stimulated IL-1ra release was normal and the IL-1ra/IL-1beta ratio was therefore increased ( P < 0.05 ) and correlated inversely to prednisolone dosage ( P = 0.009 )
Xiao et al., Neuroimmunomodulation 2000 : Cortisol secretion increased in response to LPS , but this stimulatory effect was not affected by IL-1ra ( 178.3 +/- 13.4 vs. 166.9 +/- 5.7 % )
Vaslaki et al., Artif Organs 2000 (Inflammation...) : Specifically, we measured spontaneous and lipopolysaccharide (LPS) stimulated tumor necrosis factor alpha (TNFalpha) and interleukin-1 receptor antagonist ( IL-1Ra ) release during ex vivo incubation of whole blood ... LPS stimulated release of TNFalpha and IL-1Ra was elevated for both online HDF and low-flux HD patients compared to healthy individuals ( TNFalpha : 2,336 +/- 346 and 2,192 +/- 398 versus 1,218 +/- 224 pg/106 white blood cells [ WBC ] ; IL-1Ra : 2,410 +/- 284 and 2,326 +/- 186 versus 1,678 +/- 219 pg/106 WBC )
Hartung et al., Cytokine 2000 (Carcinoma, Basal Cell...) : Ex vivo IFN-gamma release was decreased and IL-10 and IL-1ra secretion were increased in response to LPS or LTA
Maneiro et al., J Rheumatol 2001 (Osteoarthritis, Knee) : IL-1, TNF-alpha, and LPS produced dose dependent increases in synthesis of IL-1Ra
Bessler et al., Biol Neonate 2002 : In conclusion, the lower ability of CBMC of preterm newborns to produce IL-1ra in response to LPS and the absence of an IM and IB effect on the secretion of this cytokine by these cells as compared with PBMC of adults, suggest an underdevelopment of the immune response in preterm newborns
Spek et al., J Clin Immunol 2003 : LPS induced MIP-1alpha, MIP-1beta, IL-8, IL-1beta, and IL-1Ra mRNA production, which was delayed by 1 hr and reduced twofold by IC14 treatment
Vamvakopoulos et al., BMC cardiovascular disorders 2003 : Concurrent treatment with mevalonolactone prevented the induction of apoptosis and suppressed both IL-1beta and IL-1Ra release in response to LPS , suggesting a rate limiting role for HMG-CoA reductase in monocyte differentiation
Smith et al., J Immunol 1992 : In the human monocytic cell line U937, IL-1ra promoter activity was inducible by LPS or PMA treatment, but the combination of LPS and PMA led to the greatest increase in promoter activity, identical to the pattern of expression of endogenous IL-1ra mRNA as detected by polymerase chain reaction analysis
Andersson et al., Eur J Immunol 1992 : The effects of lipopolysaccharide (LPS) on IL-1 alpha, IL-1 beta and IL-1ra production was studied at a single-cell level by use of cytokine-specific antibodies and indirect immunofluorescence technique
Kline et al., J Appl Physiol 1992 : LPS caused downregulation of IL-1 RA release from monocytes but not from macrophages
Molnarfi et al., J Neuroimmunol 2004 : Here we compare modulatory effects of IFNbeta on the production of proinflammatory cytokines ( IL-1beta, IL-1alpha, TNF, and IL-6 ) and IL-1Ra in human monocytes stimulated by lipopolysaccharides (LPS) and isolated plasma membranes of stimulated T cells ( msHUT ), which are likely to reflect monocyte activation in acute and chronic inflammation, respectively
Cutolo et al., Clin Exp Rheumatol 2002 (Arthritis, Rheumatoid) : In addition, the oral administration of cortisol to normal subjects also decreased LPS induced IL-1Ra synthesis in cultured monocytes
Allgayer et al., Cancer Detect Prev 2004 (Adenocarcinoma...) : The LPS stimulated interleukin-1 receptor antagonist ( IL-1ra ) response in the ME group gradually decreased from 31,532.6 ( 160.0-70,028.0 ) to 18,033.0 pg/ml ( 5040.0-52,570.0 ) after one and to 22,892.0 pg/ml ( 6376.0-34,726.0 ) after 2 weeks ( P < 0.05 ) with a concomitant decrease of the corresponding IL-1ra/IL-6 and IL-1ra/IL-1beta ratio : 2.51-1.41 and 4.1-3.1, respectively
Granowitz et al., Blood 1992 : We consistently observed IL-1ra suppression of LPS induced cytokines in PBMC of 38 volunteers
De et al., J Immunoassay Immunochem 2005 : Neutrophils isolated using this new technique secreted significant amounts of soluble IL-1RA ( 929.3+/-197 pg/10 ( 6 ) cells/mL ) in response to lipopolysaccharide (LPS)
Stienstra et al., J Hepatol 2007 (Carcinoma, Hepatocellular...) : Up-regulation of IL-1ra by LPS was lower in PPARalpha -/- mice compared to Wt mice
Karyadi et al., Asia Pac J Clin Nutr 2007 (Tuberculosis, Pulmonary) : Zinc deficiency was associated with high LPS stimulated production of TNF-alpha and IL-1ra
Ulich et al., Am J Pathol 1991 (Pneumonia) : In conclusion IL-1ra inhibits both LPS- and IL-1 induced neutrophilic inflammation and may therefore prove clinically useful as an anti-inflammatory agent for the therapy of either septic or aseptic IL-1 mediated acute inflammation
Lin et al., Int J Radiat Biol 2008 : By contrast, SMF exposure tended to increase the level of LPS induced IL-1 receptor antagonist (IL-1Ra) and IL-6
Tamassia et al., Int Immunol 2008 (Sepsis...) : Consistent with the presence of a fully functional IL-10R, modulation of LPS induced CXCL8, CCL4, tumour necrosis factor-alpha and IL-1ra gene expression was also rapidly induced by IL-10 in septic, but not normal, neutrophils
Arend et al., J Immunol 1991 : LPS induces production of both proteins whereas adherent IgG stimulates only IL-1ra production ... The effects of IgG and LPS on induction of IL-1ra production in human monocytes are mediated at both transcriptional and post-transcriptional levels
Janson et al., J Immunol 1991 : Human monocytes were differentiated by 6 days culture in either medium or granulocyte-macrophage colony stimulating factor ( GM-CSF ), after which the effects of subsequent LPS and/or GM-CSF on the production of IL-1ra were evaluated
Na et al., Cell Immunol 2009 : 2-Aminopurine, a pharmacological PKR inhibitor, completely abrogated LPS induced expression of IL-1rn in TLR4 ( neg ) DCs, suggesting that LPS induced TLR4 independent expression of IL-1rn might be mediated by PKR pathways
Andreasen et al., Intensive Care Med 2010 (Diabetes Mellitus, Type 2...) : Type 2 diabetes was associated with less pronounced LPS induced increases in TNF, IL-1ra , VCAM-1 and ICAM-1
Qureshi et al., Lipids in health and disease 2011 (Inflammation...) : The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA , TRAF1 and CD40 )
Timper et al., Am J Physiol Endocrinol Metab 2013 (Insulin Resistance) : Furthermore, GIP potentiated IL-6 and IL-1Ra secretion in the presence of LPS , IL-1ß, and TNFa
Munro et al., Placenta 2013 : However, TSA had no significant effect on LPS induced IL-1ß, IL-1ra , IL-6 or IL-8 mRNA expression or protein production
Rice et al., Shock 1994 (Inflammation) : In contrast, CT-1501R does not inhibit LPS stimulated IL-8 or IL-1 receptor antagonist (IL-1ra) release in human whole blood or IL-1 alpha induced release of PGE2 in human foreskin fibroblast cells
Ruiz de Souza et al., Eur J Immunol 1995 : IVIg induced production of IL-8 by monocytes was enhanced by lipopolysaccharide (LPS), although LPS inhibited the secretion of IL-1ra , suggesting that IVIg and LPS stimulate distinct intracellular pathways in monocytes
Yanagawa et al., Am J Respir Cell Mol Biol 1995 : Upon stimulation with lipopolysaccharide (LPS) , AM produced a significantly amount of proinflammatory cytokines as well as IL-1ra , but this production was suppressed by IL-13 in a dose dependent manner ... In contrast, IL-13 caused a small but reproducible increase in LPS induced IL-1ra production
Arend et al., Immunol Rev 1994 : Adherent IgG and LPS induce IL-1ra production in human monocytes through different mechanisms
Smith et al., J Immunol 1994 : These results indicate that the net activation of the human IL-1ra promoter in response to LPS involves the functional interaction of at least four cis acting DNA elements within the proximal 294 bp
Ebisui et al., Am J Physiol 1994 : On the other hand, both recombinant human IL-1RA and anti-TNFAS significantly inhibited plasma ACTH increase stimulated with 10 micrograms/kg LPS
Ogawa et al., Microbiology 1994 : P. gingivalis lipid A and its LPS induced stronger or comparable production of the cytokines interleukin-1 receptor antagonist ( IL-1ra ), IL-6, IL-8, granulocyte-macrophage colony stimulating factor and interferon-gamma as compared with compounds 506 and 516 in the culture supernatants of human peripheral blood monocytes or mononuclear cells
Malyak et al., J Clin Immunol 1994 : Lipopolysaccharide (LPS) , granulocyte/macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha), individually, transiently increased IL-1ra steady-state mRNA levels in PMN, with associated increases in IL-1ra protein synthesis ... IL-4 enhanced LPS induced IL-1ra production by PMN and inhibited LPS induced IL-1 beta production
Jenkins et al., Cytokine 1993 : However, our data confirmed that IL-4 up-regulated LPS induced IL-1ra and down-regulated LPS induced IL-1 beta
Keuter et al., J Infect Dis 1994 (Acute Disease...) : LPS stimulated production of IL-1RA was higher in the acute than during the convalescent phase ( 5608 vs. 3977 pg/mL )
Romero et al., Neuroendocrinology 1993 : To test this hypothesis, the effects of IL-1 receptor antagonist (IL-1Ra) on LPS and IL-1 induced IL-6 secretion were tested in a mixed brain cell culture from 17-day fetal rat, after 12-14 days in culture
Re et al., Eur J Immunol 1993 : IL-1ra induction by LPS reached peak levels at 10 ng/ml after 3-6 h and remained sustained 24 h after stimulation
Wong et al., J Exp Med 1993 (Carcinoma, Renal Cell...) : In the presence of LPS , IL-4 not only augmented IL-1ra levels, but markedly inhibited LPS induced IL-1 mRNA expression
Krzesicki et al., J Immunol 1993 : Reverse transcriptase-polymerase chain reaction amplification demonstrated that although LPS and PMA induced both transcripts, LPS preferentially induced secreted IRAP , whereas PMA differentially induced intracellular IRAP mRNA
Sauer et al., J Clin Endocrinol Metab 1996 : Oral administration of 276 mumol cortisol to normal subjects also decreased LPS induced IL-1ra synthesis in cultured monocytes ... By coincubating the monocytes with either the mineralocorticoid antagonist spironolactone or the glucocorticoid receptor antagonist RU 38486, the in vitro cortisol induced inhibition of LPS stimulated IL-1ra secretion was partially reversed ... The mineralocorticoid aldosterone exerted a significant decrease in LPS induced monocyte IL-1ra secretion in vitro, which was blocked by coincubation with spironolactone
Pue et al., J Immunol 1996 (Acute-Phase Reaction) : C-reactive protein (CRP), the major acute phase protein in humans, was purified free of endotoxin ( LPS ) ( < 10 pg of LPS/mg of purified CRP ) and evaluated for its ability to modulate LPS induced production of IL-1 beta and IL-1 receptor antagonist (IL-1ra) from human PBMC and lung macrophages ... With respect to IL-1ra, although CRP induced IL-1ra production from PBMC ( 0.8 +/- 0.3 ng/ml control, 2.6 +/- 1.3 ng/ml with CRP ), CRP did not synergize with LPS for IL-1ra production ( 15.0 +/- 0.7 ng/ml LPS alone vs 15.4 +/- 1.4 ng/ml LPS and CRP )
Marie et al., Cytokine 1996 : IL-4 and TGF-beta were able to increase the production of IL-1ra, however only IL-4 were able to further increase IL-1ra production in the presence of LPS
Thomassen et al., Clin Immunol Immunopathol 1996 (Inflammation) : In contrast, IL-1ra was not stimulated by LPS and basal levels were not affected by IL-10
Reale et al., Mol Cell Biochem 1996 : IL-1ra may play a significant role in the control of IL-1 and LPS induction in the release of TxB2
Jenkins et al., J Immunol 1997 : However, icIL-1Ra mRNA expression was observed in response to stimulation with LPS in RAW 264.7 cells and to PMA and LPS in U937 cells ... LPS induction of icIL-1Ra transcription in RAW 264.7 cells was regulated by strong positively acting DNA regions between bases -1438 to -909 and -156 to -49
Abrahamsen et al., Bone 1997 (Osteoporosis, Postmenopausal) : In spite of a significant bone maintaining effect of ERT, the basal and LPS stimulated secretion of IL-1 alpha, IL-1 beta, and IL-1ra was identical in the two groups
Mol et al., Atherosclerosis 1997 (Diabetes Mellitus...) : The basal and LPS stimulated levels of interleukin-1 beta and tumour necrosis factor alpha (TNF alpha) and the basal level of interleukin-1-receptor antagonist ( IL-1RA ) were identical for the 3 groups ... LPS stimulated IL-1RA was higher in DM versus controls ( 10.7 +/- 2.0 versus 8.1 +/- 1.7 pmol/l, P < 0.05 )
Haku et al., Oncol Res 1996 (Lung Neoplasms) : No significant difference in spontaneous and lipopolysaccharide (LPS) stimulated IL-1 beta or IL-1ra production by AM was observed between lung cancer patients and control patients
Salkowski et al., Infect Immun 1997 : We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35, IL-12 p40, gamma interferon ( IFN-gamma ), glucocorticoid receptor ( GR ), IL-1 receptor antagonist (IL-1ra) , and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages
Gasperini et al., AIDS 1998 (HIV Infections) : In contrast, release of IL-1beta and IL-1ra ( IL-1 receptor antagonist ) in response to LPS , or LPS plus IFNgamma, was found to be lower in PMN from HIV positive patients than in PMN from controls, but was significant only in the case of IL-1ra
Kovalovsky et al., Eur J Immunol 1998 : Monocytes express IL-1 and IL-1 receptor antagonist (IL-1Ra) in response to lipopolysaccharide (LPS) ... LPS stimulated IL-1 and IL-1Ra production are inhibited by glucocorticoids ... We demonstrate that IL-1 contributes to LPS induced IL-1 Ra expression as shown by IL-1 blockade in LPS stimulated monocytes using a specific anti-IL-1beta antibody or recombinant IL-1Ra
de Bont et al., Atherosclerosis 1998 (Hyperlipoproteinemia Type II) : In a second series of experiments, HMG-CoA synthesis inhibitors were ineffective to change the LPS induced production by PBMC of IL-1alpha, IL-1beta, IL-1 receptor antagonist (IL-1ra) , IL-6, and TNFalpha
Smith et al., J Biol Chem 1998 : These data therefore suggest that the regulation of IL-1Ra gene expression is a complex event involving the interactions of three different transcription factors with a single cis acting element and that the two PU.1 binding sites are the major response elements for LPS induced IL-1Ra gene expression
Hennemann et al., Br J Haematol 1998 (Carcinoma, Renal Cell...) : In whole blood samples the lipopolysaccharide (LPS) stimulated release of TNF-alpha, IL-6 and IL-1RA increased initially, whereas IL-1beta, IL-10 and IL-12 decreased ... The differentiation associated increase of LPS induced TNF-alpha, IL-1RA and IL-10 secretion was reduced by the rhuGM-CSF treatment, and the expression of CD14 on MAC as well as the proportion of CD14+/CD16+, CD14+/MAX.1+ and CD14+/CD71+ cells in 7-d cultured MAC declined
Vonk et al., J Antimicrob Chemother 1998 (Inflammation) : We assessed the capacity of amphotericin B to modulate production of these pro-inflammatory cytokines as well as the anti-inflammatory IL-1 receptor antagonist (IL-1ra) , induced by LPS , heat killed Candida albicans or Staphylococcus aureus
Faggioni et al., Am J Physiol 1999 (Obesity) : In vitro, leptin induced IL-1Ra production and upregulated the IL-1Ra induction by LPS in macrophages