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ARG1 — CDKN1A
Text-mined interactions from Literome
Guo et al., J Biol Chem 2011
:
A citrulline mimicking
Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and
results in repression of downstream
p21 expression
Crook et al., Oncogene 1998
:
Arg283His transactivates the
p21Waf1 , Mdm2, bax, cyclin G and IGF-BP3 promoters in transient transfection assays equally as well as, if not better than WT p53