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FXR1 — SIRT1

Text-mined interactions from Literome

Kemper et al., Cell Metab 2009 (Disease Models, Animal...) : Surprisingly, in mouse models of metabolic disease, FXR interaction with SIRT1 and p300 was dramatically altered, FXR acetylation levels were elevated, and overexpression of SIRT1 or resveratrol treatment reduced acetylated FXR levels
Lee et al., J Biol Chem 2010 : Remarkably, miR-34a levels were elevated, and SIRT1 protein levels were reduced in diet induced obese mice, and FXR activation in these mice reversed the miR-34a and SIRT1 levels, indicating an intriguing link among FXR activation, decreased miR-34a, and subsequently, increased SIRT1 levels
Purushotham et al., Mol Cell Biol 2012 (Gallstones) : We provide evidence that SIRT1 regulates the expression of FXR through hepatocyte nuclear factor 1a ( HNF1a ) ... SIRT1 deficiency in hepatocytes leads to decreased binding of HNF1a to the FXR promoter