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NFKB1 — SIRT1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yeung et al., EMBO J 2004
:
In this study, we demonstrate that
SIRT1 , a nicotinamide adenosine dinucleotide dependent histone deacetylase,
regulates the transcriptional activity of
NF-kappaB
Yang et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation) :
We hypothesized that cigarette smoke mediated proinflammatory cytokine release is
regulated by
SIRT1 by its interaction with
NF-kappaB in a monocyte-macrophage cell line ( MonoMac6 ) and in inflammatory cells of rat lungs
Ghosh et al., Biochem J 2007
:
We have demonstrated using co-transfection assays that
Sirt1 and TLE1
repress NF-kappaB activity ... The catalytic mutant of Sirt1, Sirt1-H363Y, and the N-terminal Sirt1 fragment ( amino acids 1-270 ) also show similar repression activity, suggesting that the deacetylase activity of
Sirt1 may not be
critical for its effect on
NF-kappaB activity ... Furthermore, analysis in Sirt1-null MEFs ( murine embryonic fibroblasts ) and HeLa cells stably expressing siRNA ( small interfering RNA ) specific to Sirt1 or TLE1 demonstrate that both
Sirt1 and TLE1 are
required for negative regulation of
NF-kappaB activity
Pediconi et al., Mol Cell Biol 2009
:
The NAD ( + ) -dependent histone deacetylase
hSirT1 regulates cell survival and stress responses by inhibiting p53-,
NF-kappaB- , and E2F1 dependent transcription
Stein et al., Aging 2010
(Atherosclerosis...) :
However,
SIRT1 prevented endothelial superoxide production,
inhibited NF-kappaB signaling, and diminished expression of adhesion molecules ... However,
SIRT1 prevented endothelial superoxide production,
inhibited NF-kappaB signaling, and diminished expression of adhesion molecules