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PIK3CA — SIRT1

Text-mined interactions from Literome

Byles et al., International journal of biological sciences 2010 : Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells ... We found this predominant cytoplasmic localization of SIRT1 is regulated by elevated mitotic activity and PI3K/IGF-1R signaling in cancer cells ... We show that aberrant cytoplasmic localization of SIRT1 is due to increased protein stability and is regulated by PI3K/IGF-1R signaling ... Our study represents the first identification that aberrant cytoplasm localization is one of the specific alternations to SIRT1 that occur in cancer cells, and PI3K/IGF-1R signaling plays an important role in the regulation of cytoplasmic SIRT1 stability
Zong et al., PloS one 2012 (MAP Kinase Signaling System) : Meanwhile, PI3-K is essential for resveratrol mediated phosphorylation of AMPK and expression of SIRT1