Gene interactions and pathways from curated databases and text-mining

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PTK2 — VEGFA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Dougher et al., Oncogene 1999 : VEGF binding to cells expressing the native receptor led to a rapid increase in receptor and PLC-gamma phosphorylation, and a slower increase in the phosphorylation of p125FAK and paxillin
Takahashi et al., Circ Res 1999 : VEGF induced tyrosine phosphorylation and activation of p125(FAK) as well as tyrosine phosphorylation of paxillin ; this was accompanied by subcellular translocation of p125(FAK) from perinuclear sites to the focal adhesions ... This VEGF induced activation of p125(FAK) was inhibited partially by the tyrosine kinase inhibitors genistein and tyrphostin
Kim et al., J Biol Chem 2002 : Endostatin blocked VEGF induced tyrosine phosphorylation of KDR/Flk-1 and activation of ERK, p38 MAPK, and p125(FAK) in human umbilical vein endothelial cells
Drevs et al., Cancer Res 2002 (Carcinoma, Renal Cell...) : PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor , affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
Lin et al., Cancer Res 2002 (Multiple Myeloma) : Importantly, PTK787 also inhibits the increased MM cell proliferation and increased IL-6 and VEGF secretion in cultures of MM cells adherent to bone marrow stem cells
Siddiqui et al., Hematol J 2002 (Neoplasms) : We conclude that Hb-induced synthesis of VEGF in TF-bearing malignant cells is mediated by protein tyrosine kinase and by MAP-kinase pathways
Drevs et al., IDrugs 2003 : PTK/ZK , a VEGF receptor tyrosine kinase inhibitor , is under development by Novartis AG and Schering AG as an inhibitor of angiogenesis for the potential treatment of various cancers
Tsai et al., Biochem Biophys Res Commun 2003 (Glioma) : PTK inhibitors blocked glioma proliferation and epidermal growth factor (EGF) induced VEGF secretion, while H-7, a PKC inhibitor, inhibited both EGF induced and baseline VEGF secretion
Gray et al., Oncogene 2005 (Anoxia...) : In normal fibroblasts, hypoxia induced activation of the protein tyrosine kinase , Src, is required for VEGF expression
Hess-Stumpp et al., Chembiochem 2005 (Neoplasms) : PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy
Liu et al., Cancer Res 2005 (Carcinoma, Hepatocellular...) : This study examined the angiogenesis dependent and angiogenesis independent activities of PTK787/ZK222584 ( PTK787 ) , a tyrosine kinase inhibitor of VEGF receptors, in nude mice bearing human hepatocellular carcinoma xenografts
Rudin et al., NMR Biomed 2005 (Melanoma...) : PTK787/ZK222584 , a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo
Mross et al., Eur J Cancer 2005 (Liver Neoplasms...) : Phase I clinical and pharmacokinetic study of PTK/ZK , a multiple VEGF receptor inhibitor , in patients with liver metastases from solid tumours
Yazici et al., Laryngoscope 2005 (Carcinoma, Squamous Cell...) : PTK787 alone or in combination with CPT-11 reduced the phosphorylation of VEGF-R in tumor cells and tumor associated endothelial cells, was associated with decreased microvessel density, a decreased proliferative index, and an increased apoptotic index
Bian et al., Exp Eye Res 2007 : Moreover, TGF-beta2 induced RPE VEGF secretion was significantly reduced by inhibitors of mitogen activated protein ( MAP ) kinase ( MEK ) ( U0126 ), p38 ( SB202190 ), c-Jun NH2-terminal kinase (JNK), Sp600125, protein tyrosine kinase ( PTK ) ( Genistein ), and phosphatidylinositol 3-kinase (PI3K) ( Ly294002 )
Giles et al., Leuk Res 2007 (Primary Myelofibrosis) : PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor ( VEGF ), has modest activity in myelofibrosis with myeloid metaplasia
Dong et al., Biotechniques 2007 : In a proof-of-principle experiment with PTK/ZK , a small molecule inhibitor of vascular endothelial growth factor ( VEGF ) tyrosine kinase receptors, a strong correlation was observed between the decrease in bioluminescence ( 9.12-fold ) in treated mice and the actual decrease in microvessel density ( 9.16-fold ) measured after retrieval of the scaffolds and immunohistochemical staining of endothelial cells
Liu et al., Lab Invest 2009 (Disease Models, Animal...) : PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs
Schomber et al., Mol Cancer Ther 2009 (Disease Progression...) : In Rip1Tag2 mice, tumor angiogenesis is predominantly mediated by VEGF-A , and as expected, PTK/ZK efficiently impaired tumor blood vessel angiogenesis and tumor growth
Nijkamp et al., Ann Surg 2009 (Anoxia...) : PTK787/ZK-222584 , a nonselective Vascular Endothelial Growth Factor ( VEGF ) -receptor inhibitor , reduced RFA stimulated tumor growth and tumor growth in the RZ to a similar extent
Brandes et al., Eur J Cancer 2010 (Brain Neoplasms...) : PTK787/ZK222584 ( PTK/ZK, vatalanib ), a multiple VEGF receptor inhibitor , blocks the intracellular tyrosine kinase activity of all known VEGF receptors and is therefore suitable for long-term therapy of pathologic tumour neovascularisation
Abedi et al., J Biol Chem 1997 : The effect of VEGF on p125(FAK) tyrosine phosphorylation was completely inhibited by the actin filament disrupting agent cytochalasin D and was partially inhibited by the protein kinase C inhibitor GF109203X ... VEGF stimulated migration and actin stress fiber formation in confluent HUVEC, and VEGF induced p125(FAK)/paxillin tyrosine phosphorylation was accompanied by increased immunofluorescent staining of p125(FAK), paxillin, and phosphotyrosine in focal adhesions in confluent cultures of HUVECs