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MTOR — NOTCH4
Text-mined interactions from Literome
Shepherd et al., Leukemia 2013
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K/mTOR inhibition
upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Pajvani et al., Nat Med 2013
(Body Weight...) :
We demonstrate that
Notch signaling
increases mTorc1 complex stability, augmenting mTorc1 function and sterol regulatory element binding transcription factor 1c ( Srebp1c ) -mediated lipogenesis