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BCL9 — CREB5
Text-mined interactions from Literome
Aggarwal et al., Cancer Res 2008
(Carcinoma, Non-Small-Cell Lung...) :
Furthermore, treating H1734 NSCLC cells with an inhibitor of the CREB signaling pathway Ro-31-8220 inhibited
CREB activation by blocking the activity of extracellular signal kinase and ribosomal s6 kinase, arrested the cell cycle at the G(2)-M phase, and subsequently
induced apoptosis with the suppression of Bcl-2 and
Bcl-xL expression
Suzuki et al., Cancer Chemother Pharmacol 2009
(Carcinoma, Squamous Cell...) :
Suppression of 5-FU induced apoptosis by Zeb was not associated with increased Bcl-2 and
Bcl-xL expressions
dependent on transcription factor
CREB , and with the expression level of thymidylate synthase
Shi et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
Furthermore, ectopic expression of active Rit stimulates
CREB-Ser133 phosphorylation,
induces expression of the anti-apoptotic Bcl-2 and
Bcl ( XL ) proteins, and promotes cell survival