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PLD2 — RHEB

Text-mined interactions from Literome

Sun et al., Proc Natl Acad Sci U S A 2008 : Here, we find that PLD1, but not PLD2 , is required for Rheb activation of the mTOR pathway, as demonstrated by the effects of RNAi ... The overexpression of Rheb activates PLD1 in cells in the absence of mitogenic stimulation, and the knockdown of Rheb impairs serum stimulation of PLD activation
Avruch et al., Am J Physiol Endocrinol Metab 2009 : In addition, Rheb-GTP stimulates phospholipase D1 to generate phosphatidic acid, a positive effector of mTORC1 activation, and binds to the mTOR inhibitor FKBP38, to displace it from mTOR