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NOS3 — SMAD2

Text-mined interactions from Literome

Saura et al., Circ Res 2002 : Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression ... We report that Smad2 , a transcription factor activated by TGF-beta, mediates TGF-beta induction of eNOS in endothelial cells ... Overexpression of Smad2 increases basal levels of eNOS , and further increases TGF-beta stimulation of eNOS expression ... Because Smad2 can interact with a variety of transcription factors, coactivators, and corepressors, Smad2 may thus act as an integrator of multiple signals in the regulation of eNOS expression
Chen et al., Cardiovasc Pathol 2007 (Myocardial Infarction...) : Activation of tumor growth factor beta1 and Smad-2 after myocardial infarction was also dramatically reduced by endothelial nitric oxide synthase