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NCOR1 — PIK3CA

Text-mined interactions from Literome

Furuya et al., Mol Cell Biol 2007 (Thyroid Neoplasms) : Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether NCoR regulates PV-activated PI3K signaling ... Overexpression of NCoR in thyroid tumor cells of TRbetaPV/PV mouse reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT
Furuya et al., Steroids 2009 (Thyroid Neoplasms) : Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over activated PI3K-AKT signaling to increase cell proliferation and motility