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PHKA2 — PIK3CA

Text-mined interactions from Literome

Ma et al., J Neurosci 2003 (Ion Channel Gating...) : Additionally, muscarinic receptors in PFC slices activated PKC and the focal adhesion kinase Pyk2 ( a potential molecular link between PKC and Src ) in a PI3K dependent manner
Kawanabe et al., Mol Pharmacol 2003 : These results indicate that 1 ) Ca ( 2+ ) influx through NSCC-1, NSCC-2, and SOCC plays essential roles in ET-1 induced PYK2 phosphorylation, 2 ) NSCC-2 and SOCC are stimulated by ET-1 via a PI3K dependent cascade, whereas NSCC-1 is stimulated via a PI3K independent cascade, and 3 ) PI3K is involved in the PYK2 phosphorylation that depends on Ca ( 2+ ) influx through SOCC and NSCC-2
Melikova et al., Exp Hematol 2004 : Activation of PI3K following beta1-integrin engagement on human CD34+ cells results in subsequent phosphorylation of PYK2 , and is required for the recruitment of the PI3K/PYK2 complex to beta1-integrins at the cell surface
Banno et al., J Biol Chem 2005 : Furthermore, the PI3K/Akt activation in response to H ( 2 ) O ( 2 ) was reduced by transfection of either PLD2KR or the dominant negative Pyk2DN
Lin et al., Toxicol Appl Pharmacol 2008 : LPS stimulated Src, PYK2 , EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Cain et al., J Cell Biol 2010 : p110alpha selectively mediates activation of the Tyr kinase Pyk2 and GTPase Rac1 to regulate barrier function ... Additionally, p110alpha mediates the association of VE-cadherin with Pyk2 , the Rac guanine nucleotide exchange factor Tiam-1 and the p85 regulatory subunit of PI3K