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CAT — MAPK6

Text-mined interactions from Literome

Preston et al., J Biol Chem 2001 : Phosphorylation of p38 MAPK was induced by H ( 2 ) O ( 2 ) but not by catalase
Iwai-Kanai et al., Circulation 2001 (Heart Failure) : Antioxidant catalase also blocked LOX-1 induced apoptosis as well as activation of p38 MAPK
Hsieh et al., Endocrinology 2002 : Hydrogen peroxide ( > /=10 ( -5 ) M ) also stimulated p38 MAPK phosphorylation, ANG secretion, and ANG mRNA gene expression, but its stimulatory effect was blocked by catalase and SB 203580
Takaishi et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : Catalase suppressed p38 MAPK phosphorylation and MCP-1 expression
Wang et al., Free Radic Biol Med 2003 : The phosphorylation of p38 MAPK by V2O5 was inhibited by NAC and catalase , yet the EGF receptor inhibitor AG1478 had no effect on V2O5 induced p38 MAPK activation
Chen et al., Exp Eye Res 2004 : PDGF stimulated DNA synthesis and MAPK activation were eliminated in the presence of catalase or mannitol
Pawate et al., J Neurosci Res 2004 (Encephalitis...) : Phox inhibitors and catalase also suppressed LPS/IFNgamma induced expression of cytokines, i.e., interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)alpha and blocked LPS activation of MAP kinases ( i.e., p38 MAPK , c-Jun N-terminal kinase and extracellular signal regulated kinase ), NFkappaB, and IFNgamma induced STAT1 phosphorylation
Hachiya et al., Radiat Res 2005 (Leukemia, Promyelocytic, Acute) : Moreover, inhibition of catalase blocked the phosphorylation of ERK1/2 but not of p38MAPK in HP100-1 cells
Gaitanaki et al., Mol Cell Biochem 2006 : Oxidative stress was exemplified by perfusing hearts with 30 microM H ( 2 ) O ( 2 ) for 5 min or with the enzymatic system of xanthine/xanthine oxidase ( 200 microM/10 mU/ml, respectively ) for 10 min. H ( 2 ) O ( 2 ) -induced activation of p38-MAPK ( 7.04 +/- 0.20-fold relative to control values ) was totally attenuated by L-ascorbic acid ( 100 microM ) or catalase ( 150 U/ml )
Shim et al., Mol Cells 2006 (Liver Neoplasms...) : Inhibition of ERK and p38 MAPK reduced the induction of catalase activity resulting from overexpression of CAGE, and inhibition of catalase reduced CAGE promoted motility ... We conclude that CAGE enhances the motility of cancer cells by activating ERK and p38 MAPK , inducing catalase activity, and reducing ROS levels
Shastry et al., Kidney Int 2007 : Hcy increased p38-MAPK activity ( fivefold ), with maximal effect at 50 microM and 20 min ; p38-MAPK activation was attenuated by N-acetylcysteine (Nac) and catalase (Cat) , further indicating that the effect was via oxidative stress
Gaitanaki et al., J Exp Biol 2007 (MAP Kinase Signaling System) : The p38-MAPK phosphorylation induced by the combined action of CuCl ( 2 ) and hyperthermia was partially inhibited by catalase , indicating that hyperthermia possibly activates the kinase through the production of H ( 2 ) O ( 2 )
Zhang et al., Free Radic Biol Med 2007 : Activation of p38 MAPK and HIF-1alpha accumulation were attenuated by N-acetyl-L-cysteine ( antioxidant ), catalase ( hydrogen peroxide scavenger ), or a selective p38 MAPK inhibitor ( SB203580 )
Rabkin et al., Life Sci 2007 : This could not be attributed to hydrogen peroxide release from SNP as catalase did not affect SNP induced p38 MAPK phosphorylation
Gaitanaki et al., J Exp Biol 2008 : Hyperthermia induced p38-MAPK activation was found to be dependent on the Na+/H+ exchanger 1 (NHE1) and was also suppressed by catalase (Cat) and superoxide dismutase ( SOD ), implicating the generation of reactive oxygen species ( ROS )
Cheng et al., Mol Endocrinol 2010 (Ovarian Neoplasms) : In addition, PEG-catalase diminished EGF induced p38 MAPK , but not ERK1/2 or c-Jun N-terminal kinase, phosphorylation
Zhang et al., Journal of translational medicine 2013 : Mechanistically, PEP-1-CAT inhibited p38 MAPK while activating PI3K/Akt and Erk1/2 signaling pathways, resulting in blockade of Bcl2/Bax/mitochondrial apoptotic pathway