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CUL1 — MAPK6

Text-mined interactions from Literome

Bondzi et al., Cell Growth Differ 2000 (Carcinoma, Small Cell...) : In the present study, we have demonstrated that PP1, a pharmacological inhibitor of Src kinases, blocked SCF mediated activation of mitogen activated protein ( MAP ) kinase , but it also inhibited Kit activation
Sui et al., Br J Haematol 2000 : We have recently demonstrated that SCF and EPO synergistically activate mitogen activated protein ( MAP ) kinase , thereby promoting growth of human erythroid colony forming cells ( ECFCs )
Krystal et al., Clin Cancer Res 2000 (Carcinoma, Small Cell...) : STI571 efficiently blocked SCF mediated activation of mitogen activated protein kinase and Akt, but did not affect insulin-like growth factor-1 or serum mediated mitogen activated protein kinase or Akt activation
Erickson-Miller et al., Stem Cells 2000 (Leukemia, Erythroblastic, Acute) : The activation of MAPK ( p42/44 ) by SCF was transient, lasting only 30 min, in contrast to Epo, which stimulated phosphorylation of p42/44 for up to 2 h
Jeong et al., Endocrinology 2003 : Our results show that dexamethasone potently regulates SCF induced migration, p38 MAPK activation, and inflammatory cytokine production through the expression of MKP-1 protein in RPMCs
Kim et al., Toxicol Appl Pharmacol 2007 : We also showed that SC-236 suppresses the SCF induced p38 MAPK activation in RPMCs
Jeong et al., PloS one 2011 (Hypersensitivity...) : KMP6 and hesperidin inhibited SCF induced p38 MAPK activation
O'Farrell et al., Blood 1996 : Interestingly, IL-3 plus SCF synergistically activate MAPK
Sui et al., Blood 1998 : Together, the data suggest that synergistic activation of MAPK by SCF and EPO is essential for expanded erythropoiesis