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CNTNAP1 — SRC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Haskell et al., J Cell Sci 2001
:
The current study was performed to establish whether
p190RhoGAP directly participates in epidermal growth factor induced actin stress fiber disassembly and how
c-Src is
involved in this process
Wickström et al., J Biol Chem 2003
:
Subsequently, through alpha5beta1 integrin, heparan sulfate, and lipid raft mediated interactions, endostatin induced
Src dependent activation of
p190RhoGAP with concomitant decrease in RhoA activity and disassembly of actin stress fibers and focal adhesions
Meng et al., EMBO J 2004
:
Here we show that DIP binds to p190RhoGAP and Vav2, and that DIP is phosphorylated by
Src and
mediates the phosphorylation of
p190RhoGAP and Vav2 upon EGF stimulation
Miller et al., Oncogene 2004
:
RACK1 inhibits
Src mediated
p190RhoGAP signaling and actin cytoskeleton rearrangement
Lu et al., J Biol Chem 2008
:
In Nef infected podocytes,
Src kinase
induces phosphorylation of DIP,
p190RhoGAP , and Vav2, leading to RhoA inhibition and Rac1 activation
Jaffe et al., Int J Cancer 2008
(Colonic Neoplasms...) :
The
Src kinase inhibitor II (SrcKI-II) exerted a positive effect on RhoA activation,
inhibited tyrosine phosphorylation of
p190RhoGAP and inhibited leptin induced Cdc42 activation and leptin induced lamellopodium formation and cell invasion
Sachdev et al., BMC cancer 2009
(Colonic Neoplasms...) :
Specifically, in the absence of FAK,
Src induced higher phosphorylation of
p190RhoGAP , paxillin ( poY118 ) and Crk irrespective of adhesion state, PKC-delta ( poY311 ), connexin-43 ( poY265 ) and Sam68 only under adherent conditions, and p56Dok-2 ( poY351 ) and p120catenin ( poY228 ) only under suspension conditions
Putnam et al., Cell communication and signaling : CCS 2009
:
Inhibition of
Src signaling was sufficient to restore normal actin architecture, and
resulted in decreased
p190RhoGAP phosphorylation and enhanced RhoA activity
Jeon et al., Exp Mol Med 2010
:
DN-p190RhoGAP abrogated neurite outgrowth, whereas wild-type ( WT ) -p190RhoGAP and WT-Src synergistically stimulated it along with accelerating RhoA inactivation, suggesting that
p190RhoGAP , which can be
activated by
Src , is a major component in inhibiting RhoA in response to NGF in PC12 cells