UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database CXCR4-mediated signaling events: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1) (modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Thromboxane A2 receptor signaling: GNAI2/GTP complex (GNAI2) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
Gao et al., J Pharmacol Exp Ther 2001
Evidence: mutant phenotype
NCI Pathway Database Thromboxane A2 receptor signaling: GNAI2/GTP complex (GNAI2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
Gao et al., J Pharmacol Exp Ther 2001
Evidence: mutant phenotype
NCI Pathway Database Plasma membrane estrogen receptor signaling: ER alpha/Gai/GDP/Gbeta gamma complex (ESR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2) → Src (SRC) (modification, activates) Kumar et al., Mol Endocrinol 2007
Evidence: mutant phenotype