UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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PIK3CB — SRC

Pathways - manually collected, often from reviews:

KEGG VEGF signaling pathway: SRC → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1) (modification, activates)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
Reactome Reaction: PIK3CB → SRC (indirect_complex) Ruan et al., EMBO J 2012
Reactome Reaction: PIK3CB → SRC (reaction) Ruan et al., EMBO J 2012
WikiPathways Signaling Pathways in Glioblastoma: SRC → Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD (mim-stimulation)

Text-mined interactions from Literome

Gates et al., Am J Physiol Gastrointest Liver Physiol 2009 : CPT-2-Me-cAMP treatment resulted in Src dependent activation of the p110 beta and alpha subunits of PI3K, but only the latter was sensitive to inhibition with AG 1478
Jiang et al., J Biol Chem 2010 (Prostatic Neoplasms) : Basal tyrosine phosphorylation of p110beta and p110delta could be blocked by c-Src inhibitors, but this did not suppress PI3K activity, which was similarly independent of Ras