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Tsukahara et al., J Virol 1999 : Induction of Bcl-x ( L ) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax ... Transient-transfection assays showed that bcl-x promoter was transactivated by wild-type Tax ... Furthermore, Tax induced transactivation of the bcl-x promoter was also diminished by the mutant IkappaBalpha, which specifically inhibits NF-kappaB activity
Nicot et al., Blood 2000 (Leukemia-Lymphoma, Adult T-Cell) : Whereas no effect was observed on the Bcl2 promoter, both Tax1 and Tax2 increased transcription of the Bcl-X ( L ) promoter in T cells, although Tax1 appeared to be more efficient than Tax2
Mori et al., Virus Genes 2001 (Leukemia, T-Cell) : We have recently demonstrated that Tax induces the constitutive expression of the anti-apoptotic protein, Bcl-xL , in a mouse T-cell line ... We thus examined whether Tax also activates the expression of Bcl-xL in human T-cells ... Expression of Tax in a human T-cell line, Jurkat, induced the expression of the Bcl-xL gene, but did not significantly affect the expression of the other apoptosis related genes, Bcl-2 and Bax ... Transient transfection assays showed that Tax stimulated human Bcl-xL promoter activity in Jurkat cells