Sun et al., J Biol Chem 2002
:
Importantly, Bcl-2 and Bcl-x ( L ) inhibited the release of both cytochrome c and Smac from mitochondria
Hui et al., Diabetes 2005
:
All three agents induce a decrease of intracellular levels of Bcl-2 and Bcl-xL , with an increased level of Smac , indicating that they are capable of promoting a downregulation of anti-apoptotic factors and an accumulation of pro-apoptotic mediators
Yao et al., J Neurosci 2005
(Alzheimer Disease) :
We observed that Smac release was potentiated by suppression of Bcl-w and reduced by overexpression of Bcl-w