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MAPK9 — TXNIP

Text-mined interactions from Literome

Schulze et al., J Biol Chem 2004 (Diabetes Mellitus, Experimental...) : Here we show that hyperglycemia inhibits thioredoxin ROS scavenging function through p38 MAPK mediated induction of Txnip
Li et al., Biochem Biophys Res Commun 2009 : Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose treated endothelial cells
Sbai et al., J Cell Sci 2010 : TXNIP is involved in the activation of p38 MAPK , CREB and NF?B in SCs. TXNIP silencing partially inhibits RAGE induced SC migration and completely abolishes RAGE induced fibronectin and IL-1ß expression
Elgort et al., Genes & cancer 2010 : Mechanistically, Ras-MAPK and PI3K/Akt signaling inhibit TXNIP translation and MondoA dependent TXNIP transcription, respectively
Su et al., J Cell Mol Med 2013 (Hyperglycemia...) : Moreover, inhibition of p38 MAPK or activation of Akt markedly blocked HG-induced Txnip expression in I/R cardiomyocytes ... Hyperglycaemia enhances myocardial Txnip expression, possibly through reciprocally modulating p38 MAPK and Akt activation, leading to aggravated oxidative stress and subsequently, amplification of cardiac injury following MI/R