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BCL2 — CD28
Text-mined interactions from Literome
Khoshnan et al., J Immunol 2000
:
Taken together, these data demonstrate that
CD3/CD28 induced activation of IKK beta and expression of
Bcl-xL promote the survival of primary human CD4+ T lymphocytes
McKean et al., J Immunol 2001
(MAP Kinase Signaling System) :
Importantly, when TCR activated thymocytes are simultaneously coengaged by both CD28 and CD2 receptors,
CD28 signals can
inhibit ERK/MAPK dependent
Bcl-2 protein up-regulation
Kosmaczewska et al., Arch Immunol Ther Exp (Warsz) 2001
:
The interaction between the costimulatory molecule
CD28 on T cells and members of the B7 family on antigen presenting cell results in upregulation of T cell proliferation and cytokine production and
induces the expression of the anti-apoptotic protein
Bcl-xl
Tamma et al., J Leukoc Biol 2006
(MAP Kinase Signaling System) :
In the present study, we showed that stimulation of normal CD4+ T cells with jacalin plus
CD28 cross linking ( CD28XL )
resulted in phosphorylation of signal transducer and activator of transcription ( STAT ) -6 and expression of Bcl-2 and
Bcl-xL , which were inhibited significantly when cells were cultured in the presence of the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580
Yang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007
:
[
Regulation of
Bcl-2 expression in ageing T cells by CD137 and
CD28 ]
Boise et al., Curr Opin Immunol 1995
:
CD28 not only enhances IL-2 production, which can act as an extrinsic regulator of cell survival, but also
augments the expression of the intrinsic survival factor
Bcl-xL
Lin et al., J Immunol 1997
:
Furthermore,
CD28 costimulation can prevent anti-TNFR2 induced apoptosis and
restore Bcl-xL expression
Collette et al., Blood 1998
:
Conversely,
CD28 mediated signals
increase expression of
Bcl-XL , a survival gene, and promote survival of naive T cells cultured in the absence of antigen or costimulation