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BCL2 — LEP

Text-mined interactions from Literome

Brown et al., Diabetes Metab Res Rev 2007 : Leptin significantly increased the level of BCL-2 mRNA expression ( 150 % compared to serum depletion alone ), without altering Bax mRNA expression ... At the protein level, leptin increased BCL-2 and decreased Bax, altering the BCL-2 : Bax ratio
Valerio et al., Stroke 2009 (Anoxia...) : Leptin treatment activated the nuclear translocation of nuclear transcription factors kappaB dimers containing the c-Rel subunit, induced the expression of the antiapoptotic c-Rel target gene Bcl-xL in both control and oxygen-glucose deprivation conditions, and counteracted the oxygen-glucose deprivation mediated apoptotic death of cultured cortical neurons ... Leptin mediated Bcl-xL induction and neuroprotection against oxygen-glucose deprivation were hampered in cortical neurons from c-Rel ( -/- ) mice
Lam et al., Proc Natl Acad Sci U S A 2010 : We further show that leptin can induce Bcl-2 and cyclin D1 expression by two pathways, including the direct activation of their promoters and suppression of microRNAs ( miRNAs ) that target their putative 3'untranslated regions
Beaulieu et al., PloS one 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In the presence of leptin , the effect of a-linolenic acid on proliferation, survival, OB-R and BCl-2 expression was reduced
Ponemone et al., Clinical and translational gastroenterology 2010 : Leptin and APN inhibited anti-CD3-stimulated-LPL-T apoptosis and potentiated STAT3 phosphorylation, Bcl-2, and Bcl-xL expression in IBD and control mucosa ... Leptin and APN inhibited anti-CD3-stimulated-LPL-T apoptosis and potentiated STAT3 phosphorylation, Bcl-2 , and Bcl-xL expression in IBD and control mucosa
Shimabukuro et al., Proc Natl Acad Sci U S A 1998 : Leptin completely blocked FA-induced Bcl-2 suppression in normal islets but had no effect on islets from fa/fa rats, which are unresponsive to leptin because of a mutation in their leptin receptors ( OB-R ) ... However, when wild-type OB-R is overexpressed in fa/fa islets, leptin completely prevented FA-induced Bcl-2 suppression and DNA fragmentation