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BCL2 — RUNX1

Text-mined interactions from Literome

Frank et al., Oncogene 1999 (Cell Transformation, Neoplastic...) : However, AML1/ETO can also activate the BCL-2 promoter and cause enhanced hematopoietic progenitor self-renewal in vitro, suggesting gain-of-functions unique to the fusion protein
Zhuang et al., Oncol Rep 2013 : The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), reduction of histone H3 or H4 acetylation and increased trimethylation of histone H3 lysine 9 as well as lysine 27 indicating that AML1-ETO induced heterochromatic silencing of Bcl-2, CEBPA and p14ARF
Goyama et al., J Clin Invest 2013 (Leukemia, Myeloid, Acute) : The survival effect of RUNX1 was mediated by BCL2 in MLL fusion leukemia
Klampfer et al., Proc Natl Acad Sci U S A 1996 (Leukemia, Myeloid, Acute...) : Thus far, AML1/ETO has been shown to dominantly repress its target genes ; however, we found that AML1/ETO activates transcription of the BCL-2 gene in U937 cells