◀ Back to CASP5

CASP5 — TNFRSF1A

Text-mined interactions from Literome

Estellés et al., Dev Biol 1999 : The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1 mediated caspase-8 activity and apoptosis
Yin et al., Cell Res 2000 (Liver Diseases) : Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals
Fotin-Mleczek et al., J Cell Sci 2002 (Rhabdomyosarcoma) : Apoptotic crosstalk of TNF receptors : TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1 dependent activation of caspase-8 ... Compared with FasL induced cell death TNF-R1 induced activation of caspase-8 was significantly weaker and delayed ... Thus, TNF-R2 may compete with TNF-R1 for the recruitment of newly synthesized TRAF2 bound anti-apoptotic factors, thereby promoting the formation of a caspase-8 activating TNF-R1 complex
Chau et al., Nat Cell Biol 2002 (Shock, Septic) : Correspondingly, the release of cytochrome c and the activation of caspase-3 induced by TNFRI , but not by DNA damage, are defective in cells expressing Rb-MI
Wang et al., Mol Cell Biol 2004 : The pX-dependent expression of Fas/FasL and TNFR1/TNF-alpha mediates caspase 8 activation, resulting in Bid cleavage
Guthmann et al., Respir Res 2005 (Hyperoxia) : In the initiation phase of pulmonary oxygen toxicity, an increase of TNFalpha and its receptor TNFR1 leads to the activation of caspase 8 and 3 in TIIcells
Kilpatrick et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : delta-PKC associates with TNFR-1 in response to TNF and is required for NFkappaB activation and inhibition of caspase 3
Van Themsche et al., Endocrinology 2008 (Carcinoma...) : On the opposite, TNFalpha up-regulated XIAP in Hec-1A cells ; in these cells, the cytokine induced delayed TNF-R1 dependent activation of caspase-8 , and failed to activate caspases -9 and -3 and to induce apoptosis
White et al., Am J Physiol Lung Cell Mol Physiol 2012 (Acute Kidney Injury...) : We further elucidated pathways of TNFR1 mediated apoptosis with NF-?B ( Complex I ) and caspase-8 ( Complex II ) expression and discovered that TNFR1 proapoptotic signaling induces NF-?B activation
White et al., Shock 2012 (Acute Kidney Injury...) : Ischemic AKI drives distinct proinflammatory and proapoptotic changes in the pulmonary EC transcriptome with TNFR1 dependent caspase activation and programmed cell death
Kofod-Olsen et al., J Virol 2012 : Here, we report that infection by human herpesvirus 6B ( HHV-6B ) inhibited poly ( ADP-ribose ) polymerase ( PARP ) cleavage, caspase 3 and 8 activation , and I?Ba Ser-32 phosphorylation downstream of TNFR1 , indicating inhibition of both the inflammatory and apoptotic signaling pathways
Mizrahi et al., Stem Cells 2013 : Progenitor stimulation is selectively mediated by TNF-R1 and involves activation of caspase-8 , without redundant activity of TNF-R2
Srinivasan et al., J Biol Chem 1998 (Breast Neoplasms) : Thus, at least in some cells, caspase-8 signaling in response to Fas or TNFR1 stimulation is regulated by a Bcl-xL-inhibitable step
Nguyen et al., J Biol Chem 1998 : This contrasts with the anti-apoptotic influence of Bcl-2 family proteins in the cell death pathway induced by Fas ligand or tumor necrosis factor (TNF), in which Bcl-2 typically acts downstream of Fas/TNFR1 mediated activation of caspase-8 ... Moreover, E1A induces procaspase-8 processing and cell death in cells deleted of FADD, an adaptor protein critical for Fas/TNFR1 activation of caspase-8