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IGF1 — PDGFB

Text-mined interactions from Literome

Novosyadlyy et al., Lab Invest 2006 (Fibrosis...) : IGF-I and PDGF-BB differentially affected IGF-IR and PDGFR signaling ... PDGF-BB prevented IGF-I induced downregulation of the IGF-IR , but did not affect expression of its cognate receptor subunits ... In conclusion, the presented data demonstrate that the PDGFR signaling requires a functional IGF-IR and that PDGF-BB stabilizes the IGF-IR function through preventing the IGF-I induced downregulation of the IGF-IR
Risinger et al., J Biol Chem 2006 : Both PDGF-BB and IGF-I activated PI3K/Akt to similar degrees ; however, only PDGF-BB concomitantly stimulated an inhibitory signaling pathway that antagonized the effects of Akt but did not alter the extent or duration of Akt activation
Ahn et al., Annals of dermatology 2012 : IGF-I increased the expression of platelet derived growth factor (PDGF)-A, PDGF-B and the expression ratio of Bcl-2/Bax
Rydziel et al., Endocrinology 1996 : In conclusion, normal Ob cells express the PDGF-B gene, and TGF beta 1 induces its transcription, whereas bFGF, IGF-I , and PDGF-BB do not enhance the levels of PDGF-B mRNA