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IGF1 — PRKAR2A

Text-mined interactions from Literome

Makarevich et al., Biol Signals Recept 2000 : The role of cAMP/protein kinase A (PKA)- and tyrosine kinase ( TK ) -dependent intracellular mechanisms in mediating the action of porcine growth hormone (GH) on insulin-like growth factor I (IGF-I) secretion by porcine ovarian granulosa cells was studied ... The stimulation of PKA by the addition of either a cAMP agonist or a phosphodiesterase inhibitor to the medium increased IGF-I release by the cells, indicating a direct stimulation of IGF-I release by cyclic nucleotides
Billiard et al., J Biol Chem 2001 : IGF-I production by rat osteoblasts is stimulated by activation of cAMP dependent protein kinase (PKA) ... Inhibition of active PKA with targeted nuclear expression of PKA inhibitor had no effect on the subcellular location of C/EBPdelta but prevented hormone induced IGF-I gene activation, while cytoplasmic PKA inhibitor additionally caused the removal of C/EBPdelta from the nucleus
Sirotkin et al., Reprod Nutr Dev 2002 : The expression of the PKA regulatory subunit was increased by EGF ( 51 % compared with 29 % in the control, p < 0.05 ), but not by IGF-I or IGF-II ( 30 and 29 % )
Sirotkin et al., J Reprod Dev 2003 : These observations demonstrate the involvement of IGF-I and OT in the control of ovarian follicular size and follicular cell proliferation, progestagen, estrogen, IGFBP-3, inhibin A and B secretion and in cAMP/PKA- and MAPK/ERK1 dependent intracellular mechanisms
Méndez et al., Mol Cell Endocrinol 2005 : Furthermore, insulin and IGF-I blocked the activation of PKA induced by sLH and these effects were correlated with changes in the total protein content of the catalytic ( C ) and type II regulatory ( RII ) subunits of PKA
Subramaniam et al., J Neurosci 2005 : IGF-1 activated the protein kinase A (PKA) to mediate ERK inhibition via c-Raf phosphorylation at an inhibitory site ( Ser259 )
Fernández et al., J Mol Endocrinol 2005 : IGF-I and VIP stimulation of CRE mediated transcription required activation of both Ras-MAPK and cAMP/PKA signaling
Makarevich et al., Horm Metab Res 2010 : A PKA inhibitor, KT 5720 suppressed the expression of PKA and MAPK/ERK1,2, the IGF-I release, and the ratio of PCNA positive cells in granulosa cells ... These observations confirm the involvement of PKs in control of basic ovarian functions and demonstrate the involvement of PKA in stimulation of ovarian cell proliferation and MAPK ( but not CDK ) and in promotion of ovarian IGF-I release
Kachra et al., Endocrinology 1994 : The synergistic augmentation of hepatocyte IGF-I mRNA levels by GH and glucagon involves the activation of PKA and PKC, but also appears to require the synthesis of one or more protein ( s )
LaVoie et al., Endocrinology 1999 : IGF-I significantly augmented PKA pathway agonist activation of the StAR promoter, whereas IGF-I had no effect alone