Bujalska et al., Endocrinology 1999
:
Both cortisol and insulin increased the differentiation of ASC to adipocytes ( as assessed by glycerol-3-phosphate dehydrogenase expression ), but only cortisol increased 11betaHSD1 activity and messenger RNA levels in a dose dependent fashion
Handoko et al., J Steroid Biochem Mol Biol 2000
:
Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells
Whorwood et al., J Clin Endocrinol Metab 2001
(Insulin Resistance) :
In contrast, 11betaHSD1 was down-regulated by insulin ( 20-100 mU/mL : P < 0.01 ) in the presence of 20 % serum, whereas incubation with insulin under serum-free conditions resulted in a dose dependent increase in 11betaHSD1 activity ( P < 0.05 ) ... Additionally, insulin and insulin-like growth factor I regulation of 11betaHSD1 may represent a novel mechanism that maintains insulin sensitivity in skeletal muscle tissue by diminishing glucocorticoid antagonism of insulin action
Westerbacka et al., Diabetologia 2006
(Body Weight...) :
The expression of ` insulin-resistance genes ' HSD11B1 and IL6 was increased by insulin in the insulin-resistant group, but insulin failed to increase HSD11B1 expression in the insulin-sensitive group