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MAPK13 — NPY6R
Text-mined interactions from Literome
Liang et al., J Biol Chem 1999
:
In addition, we show that Ang II-induced serine phosphorylation of STAT3 in VSMCs is mediated by
mitogen activated protein kinase and that dephosphorylation is
mediated by protein
phosphatase 2A (PP2A)
Oak et al., Mol Pharmacol 2001
:
The Src-family tyrosine kinase inhibitor
PP2 blocked
MAPK activation by dopamine ; however, this drug was also found to inhibit PDGF-BB stimulated ERK activity and autophosphorylation of the PDGF receptor-beta
Aydemir-Koksoy et al., J Biol Chem 2001
:
Both ouabain induced DNA synthesis ( BrdUrd uptake ) and
MAPK42/44 phosphorylation were
inhibited by the Src inhibitor
PP2 , the EGFR kinase inhibitor AG1478, the tyrosine kinase inhibitor genistein, and the MEK1 inhibitor PD98059
Cuadrado et al., J Biol Chem 2003
(Breast Neoplasms...) :
N-Acetylcysteine and
PP2 also partially
inhibited JNK and p38
MAPK activation
Lee et al., J Cell Physiol 2003
:
The aim of this study was to examine the
role of protein
phosphatase type 2A (PP2A) in regulating p38
MAPK activation in bovine aortic endothelial cells exposed to cyclic strain
Sugawara et al., Cell Signal 2007
:
The activation of p38
MAPK was
inhibited by the Src family tyrosine kinase inhibitor
PP2 and the cholesterol depleting agent methyl-beta-cyclodextrin, which is generally used for the disruption of lipid rafts
Smolinska et al., Mol Immunol 2008
:
Interestingly, however,
PP2 had no significant effect on the activation of NF-kappaB, or on p42/44 ERK, p46/54 JNK or p38
MAPK phosphorylation
Li et al., J Biol Chem 2008
:
PP2 , a Fyn-specific inhibitor,
blocked JAK2, STAT3, and p38
MAPK activation and significantly attenuated apoptosis induced by H ( 2 ) O ( 2 )
Ohama et al., J Biol Chem 2010
:
Transient expression of either VCP/p97 or
PP2Ac was
sufficient to elevate levels of the dual specificity phosphatase DUSP1, reduce p38
MAPK activation, and suppress tumor necrosis factor-alpha release
Brock et al., Plant Physiol 2010
:
Importantly, altered
PP2C5 levels
affect MAPK activation
Sim et al., Korean J Parasitol 2010
:
Moreover, genistein and
PP2 blocked the phosphorylation of ERK and p38
MAPK in neutrophils induced by E. histolytica
Ungefroren et al., Curr Cancer Drug Targets 2011
:
Likewise,
PP2 and PP1 but not SU6656 effectively
blocked TGF-ß1 induced activation of Smad2 and p38
MAPK and partially suppressed Smad activation and transcriptional activity on TGF-ß/Smad-responsive reporters of a kinase-active TßRI mutant ectopically expressed in Panc1 cells
Wallet et al., J Leukoc Biol 2012
(MAP Kinase Signaling System) :
The HIV-1 protease inhibitor nelfinavir activates
PP2 and
inhibits MAPK signaling in macrophages : a pathway to reduce inflammation
Li et al., Brain Res Bull 2013
:
Moreover,
PP2 inhibited the up-regulation of p-p38
MAPK induced by rrTNF