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MAPK13 — PIK3CA

Text-mined interactions from Literome

Sánchez-Margalet et al., J Cell Physiol 2000 : In order to study the role of phosphatidylinositol-3-kinase (PI3K), PKB, FRAP, S6 kinase, and MAP kinase in insulin stimulated glycogen synthesis, we used a specific inhibitor of PI3K , LY294002, the immunosuppressant inhibitor of FRAP, rapamycin, and the inhibitor of MAPK kinase ( MEK ) /MAPK , PD98059, in rat HTC hepatoma cells overexpressing human insulin receptors
Gonzalez-Robayna et al., Mol Endocrinol 2000 : Lastly, FSH mediated phosphorylation of p38MAPK is negatively affected by A kinase and PI3-K , suggesting that it may be downstream of specific members of the cAMP-GEF/Rap/Raf pathway
Carrillo et al., Endocrinology 2001 : However, this PI 3-K inhibitor also reduced insulin mediated phosphorylation of p44/p42 MAPK in cultured rat hepatocytes, indicating that both the PI 3-K and MAPK pathways could be involved in PK-L activation by insulin
Reyes-Reyes et al., J Cell Sci 2001 (Leukemia) : We found that integrins activated both NF-kappaB and MAPK in a PI 3-K dependent manner, as wortmannin and LY294002 blocked these responses
Li et al., Mol Cell Neurosci 2001 : PI3K inhibitors that blocked NRG mediated rescue also blocked the phosphorylation of Akt, MAPK , and Bad
Park et al., J Leukoc Biol 2002 : Thus, the results of this work suggest that p43 should induce cell-cell adhesion via the PI3-K/ERK- and p38 MAPK dependent up-regulation of ICAM-1
Qiao et al., Hepatology 2002 : Activation of MAPK was partially blocked by inhibitors of PI3K
Liu et al., J Biol Chem 2002 : EtOH also activated p44/42 mitogen activated protein kinase in a PI3K dependent manner
Iijima et al., Circulation 2002 : To elucidate the signaling mechanism underlying the RWP effects, we investigated the effects of RWPs on the activity of PI3K and the phosphorylation of MAPK pathways in PDGF-BB stimulated SMCs. RWPs inhibited the PI3K activity and p38 ( MAPK ) phosphorylation, but not ERK1/2 phosphorylation, in a concentration dependent manner
Tsang et al., Biochem Biophys Res Commun 2002 (MAP Kinase Signaling System) : PD098059 and U0126, two MAPK kinase inhibitors, and LY294002, a PI3K inhibitor , significantly blocked thrombin induced [ ( 3 ) H ] thymidine incorporation and cyclin D(1) expression in ASM cells
Patel et al., Diabetes 2003 : None of the inhibitors significantly inhibited protein content over 20 days, but lipid content and lipogenic activity were inhibited by p70 ( S6 ) kinase and p38 MAPK inhibition but not by p42/44 MAPK or PI3K inhibition
Sandra et al., Oral Oncol 2004 (Ameloblastoma...) : MK could induce phosphorylation of p44/42 MAPK ( Thr202/Tyr204 ) and Akt ( Ser473 and Thr308 ), and by pretreatment of PD98059, MEK1 inhibitor, or LY294002, PI3K inhibitor, MK-stimulated-phosphorylation of MAPK and Akt and MK-stimulated growth of AM-1 cells were inhibited
Halevy et al., Exp Cell Res 2004 (MAP Kinase Signaling System) : Moreover, the finding that PI3K activity is required for HGF induced MAPK activation suggests its additional role in proliferation, rather than exclusively in the differentiation of adult myoblasts
Gerling et al., Neurochem Int 2004 : Accordingly, inhibition of PI3-K by wortmannin and MAPK-kinase ( MEK ) inhibition by UO126 abolished the neuroprotective effects
Wu et al., J Neurochem 2004 : Thus, AMPA receptors protect neurons through a mechanism involving BDNF release, TrkB receptor activation, and a signaling pathway involving a PI3-K dependent activation of MAPK that increases BDNF expression
Pasapera et al., J Steroid Biochem Mol Biol 2005 : Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked ( approximately 90 % ) by H89 ( PKA inhibitor ) and LY294002 but not by Wortmannin ( PI3-K inhibitors ), 4-OH-tamoxifen, ICI182,780 or SB203580 ( p38 MAPK inhibitor ) ; PD98059 ( ERK1/2 inhibitor ) partially ( approximately 30 % ) blocked the FSH mediated effect
Rahimi et al., J Immunol 2005 : IL-10 induced the phosphorylation of PI3K and p42/44 ERK MAPK
Badr et al., J Immunol 2005 (HIV Infections) : Unlike CXCL12, gp120 did not induce the activation of phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38 MAPK activation was observed
Jung et al., J Clin Immunol 2005 (MAP Kinase Signaling System...) : The inhibition of PI 3-K did not significantly activate p38 MAPK or ERK 1/2 in PPD stimulated human monocytes
Park et al., Toxicol Appl Pharmacol 2006 (Lymphoma) : In contrast, the enhanced AP-1 DNA binding activities and p38 MAPK phosphorylation were significantly suppressed by specific inhibitors for PKC and p38 MAPK, but not by PI3-K inhibitors
Bando et al., Exp Eye Res 2006 (MAP Kinase Signaling System...) : We performed the gel contraction assay to evaluate the effect of PDGF in cultured ARPE-19 cells under the presence or absence of PD98059, MAPK inhibitor or wortmannin, PI3K inhibitor
Xu et al., Am J Physiol Lung Cell Mol Physiol 2006 (Hyperoxia...) : Taken together, these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS, activation of ERK/MAPK , and PI3K-Akt cell survival signaling pathways
Punn et al., Mol Endocrinol 2006 : UCN I effect on p38 MAPK phosphorylation was more transient, returned to basal within 40 min and was dependent on epidermoid growth factor receptor transactivation, but not PI3-K/Akt activation
Pathak et al., J Immunol 2006 : TLR4/PI3K dependent ERK1/2 and p38 MAPK signaling converged upon activation of mitogen- and stress activated protein kinase 1 ( MSK1 )
Nakatani et al., Biochem Biophys Res Commun 2007 : Treatment of 3Y1 cells with AVP resulted in transient activation of p44/42 mitogen activated protein kinase ( MAPK ) and cPLA(2)alpha, and phosphatidylinositol 3-kinase (PI3K) inhibitor blocked not only AVP induced PGE ( 2 ) synthesis but also MAPK activation, suggesting that PI3K is involved in the AVP induced MAPK and cPLA(2)alpha activation, which initiates the production of PGE ( 2 )
Chuang et al., Endocrinology 2007 (Diabetes Mellitus, Experimental...) : MAPK/ERK inhibitor PD98059 inhibited the PI3K activity, Akt phosphorylation, and lipid accumulation triggered by HG
Roztocil et al., J Surg Res 2007 : Activation of p38 ( MAPK ) and ERK 1/2 was completely inhibited by the PI3-K inhibitors
Muñoz-Alonso et al., J Pharmacol Exp Ther 2008 (Melanoma) : Plitidepsin cytotoxicity diminishes by Rac1 inhibition or by the blockage of JNK and p38 MAPK using 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB203580 ), but not by PI3K inhibition using wortmannin or 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ( LY294002 )
Lee et al., Int Immunopharmacol 2008 : Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen activated protein ( MAP ) kinases , but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K
Abair et al., Blood 2008 (Neovascularization, Pathologic) : Integrin alpha1beta1 dependent endothelial cell proliferation is primarily mediated by ERK activation, whereas migration and tubulogenesis require both p38 MAPK and PI3K/Akt activation
Tachado et al., J Biol Chem 2008 (HIV Infections...) : Pharmacological inhibition of PI3K ( LY294002 ) normalized TNF-alpha release in HIV+ macrophages and augments ERK1/2 mitogen activated protein kinase phosphorylation in response to lipid A. Importantly, HIV+ macrophages demonstrated increased constitutive phosphatidylinositol 3,4,5-trisphosphate formation, increased phosphorylation of downstream signaling molecules Akt and glycogen synthase kinase-3beta ( GSK-3beta ) at Ser9, and reduced PTEN protein expression
Gayer et al., J Biol Chem 2009 : Strain MAPK activation required PI3K but not AKT
Liu et al., Biochem Biophys Res Commun 2009 (Ovarian Neoplasms) : We discovered a stem cell factor (SCF) triggered, MEK1 independent, and PI3K dependent MAPK activation pathway in the Kit expressing ovarian cancer cell line HEY
Hardy et al., Immunology 2009 : Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Chang et al., Biochem J 2009 (Ovarian Neoplasms) : The anti-apoptotic ability was suppressed and the expression of Bcl-2 family in response to mesothelin was altered by inhibiting PI3K activity, but not by inhibiting MAPK activity
Ito et al., Anim Sci J 2010 : In this study the effect of a PI3K inhibitor, LY294002, on the MAPK and p34 ( cdc2 ) kinase activities of matured porcine oocytes was examined
Tung et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Inhibition of PI3K by Wortmannin attenuated EV71 induced Akt and p42/p44 MAPK phosphorylation, but had no effect on PDGFR phosphorylation, suggesting that PDGFR is an upstream and p42/p44 MAPK is a downstream component of PI3K/Akt in these responses
Wang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010 (Myocardial Reperfusion Injury) : However, compared with H/R group, these changes were significantly attenuated in GLP-1 + H/R group [ the activity of LDH ( 128.47 +/- 7.96 ) U/L vs. ( 223.96 +/- 22.10 ) U/L, P < 0.01, and cardiomyocyte apoptosis rate ( 2.84 +/- 2.56 ) % vs. ( 12.58 +/- 6.69 ) %, P < 0.01, and Caspase-3 activity ( 36,809 +/- 4750 ) RLU vs. ( 57,602 +/- 9161 ) RLU, P < 0.01 ], while LY294002 ( PI3K inhibitor ) and UO126 ( MAPK inhibitor ) could block the effects of GLP-1 in cardiomyocytes underwent H/R injury
Yang et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Inhibitors of PI3K ( LY294002 and Wortmannin ) prevented the phosphorylation of ERK1/2, p38 MAPK , and Akt PI3K )
Yin et al., J Mol Med (Berl) 2011 (Disease Models, Animal...) : Our results demonstrated that administration of Rg1 increased VEGF expression levels, activated PI3K/Akt , and inhibited p38 MAPK in vitro and in vivo ... Rg1 induced activation of PI3K/Akt also contributed to the downregulation of p38 MAPK
Wang et al., J Cell Mol Med 2012 (Carcinoma, Hepatocellular...) : Tumour necrosis factor-a (TNF-a) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 ( p38 MAPK inhibitor ), PD98059 ( ERK inhibitor ), LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor )
Kim et al., Immune network 2011 : Furthermore, PI3-K activity was required for the HBHA induced activation of ERK1/2 and p38 MAPK , but not JNK, pathways
Lasala et al., Am J Physiol Endocrinol Metab 2011 : Blocking PKA abolished the effect of cAMP on Sox9, Sf1, and Gata4 expression, inhibiting PI3K/PKB impaired the effect on Sf1 and Gata4, and reducing MEK1/2 and p38 MAPK activities curtailed Gata4 increase
Gao et al., EMBO Mol Med 2012 (Disease Models, Animal...) : This involved p38 MAPK activation by PI3K to facilitate clathrin mediated ErbB receptor endocytosis
Ren et al., J Biol Chem 2012 (Cell Transformation, Viral...) : Tax2 efficiently immortalized CD4 ( + ) memory T lymphocytes with a CD3/TCRaß/CD4/CD25/CD45RO/CD69 immunophenotype, promoted constitutive activation of PI3K/Akt , I?B kinase/NF-?B, mitogen activated protein kinase , and STAT3, and it also increased the level of Mcl-1
Yang et al., J Mol Med (Berl) 2013 (Endotoxemia...) : LPS caused p38 MAPK- , JNK-, and PI3K/AKT mediated Mcl-1 stabilization and prevented apoptosis, and LPS induced GSK-3ß inactivation mainly through p38 MAPK and PI3K/AKT
Tapia-Abellán et al., Liver Int 2013 (Liver Cirrhosis) : The release of the pro-inflammatory cytokines IL-6 and TNF-a at baseline was more effectively reduced by the MAPK inhibitors, while the basal IL-10 anti-inflammatory cytokine secretion was only and strongly ( 90.3 % ) affected by the PI3K inhibitor
Hsieh et al., Chem Biol Interact 2013 (Breast Neoplasms) : Additionally, treatment of SB203580 ( p38 MAPK inhibitor ) or wortmannin ( PI3K inhibitor ) resulted in a reduced activity and expression of MMP-2 as well as inhibition on cell migration and invasion in MDA-MB-231 cells
King et al., Mol Cell Biol 1997 : Phosphatidylinositol 3-kinase is required for integrin stimulated AKT and Raf-1/mitogen activated protein kinase pathway activation
Lin et al., Biochem Biophys Res Commun 1998 (Carcinoma, Hepatocellular...) : Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen activated protein kinase activation by insulin but not by TPA