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MAPK13 — SERPINE1
Text-mined interactions from Literome
Webb et al., J Cell Biol 2001
(Breast Neoplasms) :
In MCF-7 cells,
PAI-1 did not directly
activate the
mitogen activated protein ( MAP ) kinases , extracellular signal regulated kinase ( ERK ) 1 and ERK2, but instead altered the response to uPA so that ERK phosphorylation was sustained
Norata et al., Br J Haematol 2004
:
Moreover, incubation with specific inhibitors of these kinases showed that
p38MAPK was mainly
involved in the Ox-HDL3 dependent
PAI-1 induction
Guo et al., Kidney Int 2005
(MAP Kinase Signaling System) :
MAPK/AP-1 dependent regulation of
PAI-1 gene expression by TGF-beta in rat mesangial cells
Mukai et al., Am J Physiol Heart Circ Physiol 2007
:
The induction of
PAI-1 by TNF-alpha and insulin is
mediated , in part, by ERK and p38
MAPK
Yang et al., Exp Cell Res 2007
:
Regulation of
TGF-beta1/MAPK mediated
PAI-1 gene expression by the actin cytoskeleton in human mesangial cells ... Our hypothesis is that the actin cytoskeleton is involved in
TGF-beta1/MAPK mediated
PAI-1 expression in human mesangial cells
Pasten et al., Thromb Res 2007
(MAP Kinase Signaling System) :
An inhibitor of p38
MAPK had no effect on polyphenol induced repression of
PAI-1
Bryan et al., Mol Cancer Res 2008
(Brain Neoplasms...) :
Accordingly, the inhibition of
mitogen activated protein kinase/extracellular signal regulated kinase kinase 1/2 and Rho-kinase, two downstream signaling cascades activated by S1P(2),
blocked the activation of
PAI-1 and uPAR mRNA expression by S1P
Nakajima et al., Neurosci Lett 2010
:
In the present study, we investigated the relationship between
MAPK activity and
PAI-1 induction in PLGn stimulated astrocytes