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MAPK13 — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lin et al., Am J Physiol 1999
:
T4-directed
STAT1alpha Ser-727 phosphorylation is
MAPK mediated and results in potentiated STAT1alpha activation and enhanced IFN-gamma activity
Kovarik et al., Proc Natl Acad Sci U S A 1999
(MAP Kinase Signaling System) :
Stress induced phosphorylation of
STAT1 at Ser727
requires p38
mitogen activated protein kinase whereas IFN-gamma uses a different signaling pathway ... An essential
role for p38
MAPK activity in
STAT1 Ser727 phosphorylation was confirmed by using cells expressing an SB203580-resistant p38 MAPK
Takauji et al., J Leukoc Biol 2002
:
CpG-DNA induced IFN-alpha production involves p38
MAPK dependent
STAT1 phosphorylation in human plasmacytoid dendritic cell precursors ... These results suggest that CpG DNA induces p38
MAPK dependent phosphorylation of
STAT1 in a manner independent of IFN-alpha/beta, which may cause ISGF3 formation to increase the transcription of the IRF-7 gene, thereby leading to IFN-alpha production in human PDC
Xu et al., Mol Cell Biol 2003
:
Interleukin-13 induction of 15-lipoxygenase gene expression requires p38
mitogen activated protein kinase mediated serine 727 phosphorylation of
Stat1 and Stat3
Nguyen et al., J Interferon Cytokine Res 2003
:
Analyses of mutant I1A cells, which lack the IL-1 receptor associated kinase (IRAK), and of I1A cells reconstituted with deletion mutants of IRAK show that the IL-1 mediated phosphorylation of
Stat1 on serine requires the IRAK protein but not its kinase activity and does not
involve phosphatidylinositol-3'-kinase (PI3K) or the
mitogen activated protein ( MAP ) kinases p38 or ERK
Wang et al., Free Radic Biol Med 2003
:
V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and
STAT-1 activation by V2O5 or H2O2 was
attenuated by an inhibitor of the EGF receptor tyrosine kinase ( AG1478 ) or p38
MAPK ( SB203580 ) ... Moreover, p38
MAPK and EGF receptor activation are
required for V2O5 induced
STAT-1 activation
Choudhury et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Inhibition of
MAPK activity
blocked IFN-gamma induced serine phosphorylation of
STAT1alpha ; but its tyrosine phosphorylation and DNA binding were partially inhibited
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Inhibitors of Janus kinase ( JAK ), p38
MAPK , and MAPK/ERK kinase (MEK)
suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB,
STAT1 , and IRF-1 activities
Kanda et al., Eur J Immunol 2007
:
Inhibitors of PI3 K, p38
MAPK , and MEK
suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB,
STAT1 , and IRF-1 activities
Hu et al., J Invest Dermatol 2008
(Adenocarcinoma...) :
Although
STAT1 phosphorylation
required JNK and
p38MAPK activation, only JNK activation was essential for IRF1 promoter activation by Tie2-R849W
Yang et al., Microvasc Res 2009
(AIDS Dementia Complex) :
Inhibitors of STAT1,
mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ),
blocked gp120 induced
STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
Benco et al., Reproduction 2009
:
Overexpression of
STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT ( from stimulatory to inhibitory ), BCL2, P ( 4 ) ( from inhibitory to stimulatory ), prevented ghrelin effect on caspase-3 and BAX, but did not
affect ghrelin 's effect on
MAPK/ERK1,2 expression
Bhattacharjee et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Further, we found that Src tyrosine kinase mediated activation of p38
MAPK is
required for
Stat1 and Stat3 serine 727 phosphorylation in alternatively activated monocytes/macrophages
Blank et al., Exp Cell Res 2013
:
We first found that p38
MAPK is
involved in serine
STAT1 phosphorylation, since a reduction of phophoserine-STAT1 levels was evident after incubating WISH cells with cyclic peptide in the presence of a p38 pharmacological inhibitor or a dominant negative p38 mutant ... In conclusion, we herein demonstrated that
STAT1 serine phosphorylation is
mediated by the sequential activation of PI3K, PKCd and p38
MAPK
Rajotte et al., Blood 1996
:
Finally, expression of a dominant negative MAPK mutant, ERK192A, resulted in a decrease of both SRE- and SIE dependent activation of c-fos promoter by GM-CSF, suggesting that
STAT1/3 are
regulated not only by tyrosine kinases, but also partially by
MAPK
Nishiya et al., FEBS Lett 1997
(Glioma) :
Activation of
Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is
independent of interferon-gamma induced
MAPK activation that is mediated by p21ras ... Recent studies have reported that
MAPK is
responsible for serine phosphorylation of
Stat1 which is required for Stat1 's DNA binding and maximal transcriptional activity