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CXCR4 — MMP2

Text-mined interactions from Literome

Su et al., Zhonghua Yi Xue Za Zhi 2005 (Lung Neoplasms...) : The effect of CXCR4 expression on the cell migration, MMP-2 activity, adhesion and GRO-a expression of lung cancer cells were detected by chemotaxis and chemoinvasion assay, zymography, adhesion assay and RT-PCR respectively
Yuecheng et al., Eur J Cancer Prev 2007 (Neoplasm Invasiveness...) : Moreover, SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level
Laird et al., Hum Reprod 2011 : Expression of CXCL12 and CXCR4 in human endometrium ; effects of CXCL12 on MMP production by human endometrial cells
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Maddirela et al., Int J Oncol 2013 (Glioblastoma...) : External supplementation of either rhMMP-2 or rhSDF-1 counteracted and noticeably reversed pM.si inhibited SDF-1, CXCR4, phospho-PI3K and phospho-AKT expression levels and angiogenesis, thereby confirming the role of MMP-2 in the regulation of avß3 mediated SDF-1/CXCR4 signaling ... Collectively, our data demonstrate the role of MMP-2 in the regulation of SDF-1/CXCR4 signaling mediated angiogenesis in ECs and show the anti-angiogenic efficacy of combining MMP-2 downregulation and IR when treating patients with GBM in the future
Pan et al., Mol Biol Rep 2013 (MAP Kinase Signaling System...) : Overall, our results demonstrate that SDF-1a/CXCR4 upregulates MMP-2 expression and induces pancreatic cancer cell invasion in PANC-1 and SW-1990 cell lines by activating p38 MAPK