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MTOR — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yarosh et al., Photodermatol Photoimmunol Photomed 2000
:
However, UV-B also induced expression of membrane bound
TNFalpha , and this was
dependent on
FRAP signaling
Gao et al., J Biol Chem 2003
(Insulin Resistance) :
Phosphorylation of Akt and the
mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in
response to
TNF-alpha was inhibited by aspirin treatment
Dan et al., J Immunol 2008
:
In this study, we have explored the involvement of both IKKalpha and IKKbeta in insulin- and
TNF induced
mTOR activation ... In MCF7 cells,
TNF does not activate Akt and
requires IKKbeta to activate
mTOR
Rosner et al., Mutat Res 2008
(Alzheimer Disease...) :
Recently, it has been recognized that
mTOR is
regulated by
TNF-alpha and Wnt, both of which have been shown to play critical roles in the development of many human neoplasias
Baker et al., Mol Immunol 2009
:
Pharmacologic inhibition of
mTOR with rapamycin inhibited LPS induction of IL-10 mRNA and protein, and
enhanced the expression of TF and the proinflammatory cytokine
TNFalpha in WT PMs
Tsou et al., J Cell Biochem 2010
:
TNF-alpha also
increased the Akt and
mTOR phosphorylation
Li et al., J Immunol 2011
(HIV Infections...) :
Furthermore,
mTOR inhibition
augmented LA-induced
TNF-a release through enhanced and prolonged phosphorylation of ERK1/2 and JNK1/2 MAPK, which was associated with time dependent MKP-1 destabilization ... Targeted gene silencing of MyD88 ( short hairpin RNA ) and
mTOR ( RNA interference ) inhibition
resulted in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced
TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Zhang et al., Basic Res Cardiol 2012
(Calcium Signaling...) :
The aim of this study was to investigate the
role of
Na/K-ATPase/mTOR signaling in myocardial
TNF-a expression during endotoxemia
Spentzas et al., International journal of inflammation 2012
:
These findings suggest that NMDA induced
TNF suppression can be
augmented by concurrent
mTOR inhibition