Gene interactions and pathways from curated databases and text-mining

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AR — RELA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Delfino et al., Mol Cell Endocrinol 2003 : NF-kappaB and TNF-alpha stimulate androgen receptor expression in Sertoli cells
Lee et al., Prostate 2005 (Prostatic Neoplasms) : Requirement for NF-(kappa)B in interleukin-4 induced androgen receptor activation in prostate cancer cells
Lee et al., Prostate 2008 (Prostatic Neoplasms) : Previous studies demonstrated that IL-4 enhances androgen receptor (AR) activation mediated by NF-kappaB in the absence or in the very low levels of androgen in prostate cancer cells
Papadopoulou et al., Molecular cancer 2008 (Prostatic Neoplasms) : Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells
Zhang et al., Am J Pathol 2009 (Prostatic Neoplasms) : NF-kappaB regulates androgen receptor expression and prostate cancer growth
Nadiminty et al., Cancer Res 2010 (Disease Progression...) : Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells
Keller et al., J Biol Chem 1996 (Prostatic Neoplasms) : It did not appear that 5alpha-dihydrotestosterone inhibited NFkappaB by activating the androgen receptor to compete for the NFkappaB response element as we could not detect androgen receptor binding to the IL-6 promoter by DNase I footprinting assay